EPISODIC MEMORY IN RHESUS MONKEYS SPATIAL & TEMPORAL CONTEXTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 人类的意识记忆分为两种类型。语义记忆由关于世界的事实组成：沙漠中缺水;海鲜必须新鲜才安全。情景记忆还有助于回忆自传体事件：在沙漠徒步旅行中，水用完了;在海滩派对上，你被变质的蛤蜊弄得恶心。虽然许多实验表明猴子和其他动物都有记忆，但事实证明，在非人类中很难区分语义记忆和情景记忆。开发出区分猴子这两种记忆类型的程序，将使我们能够更有效地利用非人类模型系统来理解正常的人类认知和影响它的疾病。 我们已经开始在实验室里训练猴子进行一个大型的野外“觅食”记忆测试。我们已经成功地训练了猴子在这个开放领域的背景下物体的歧视，并已开始训练匹配的样本。猴子在获得这项任务方面一直很慢，部分原因是空间偏见。在这项工作中，我们现在采取了两种截然不同的方法，一种强调空间记忆，另一种强调对未来事件的预期。通过这项工作，实验室完成了一系列的5个行为实验。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Conscious memory in humans is divided into two types. Semantic memory consists of facts about the world: water is scarce in the desert; seafood must be fresh to be safe. Episodic memory sub-serves the ability to recall autobiographical events: once running out of water on a desert hiking trip, the time you were sickened by spoiled clams at a beach party. While many experiments show that monkeys and other animals remember, it has proven difficult to make this important distinction between semantic and episodic memory in nonhumans. Developing procedures for distinguishing between these two types of memory in monkeys will permit us to make more effective use of nonhuman model systems for understanding normal human cognition and the diseases that affect it. We have begun training monkeys in a large open-field "foraging" memory test in the lab. We have successfully trained monkeys in object discriminations in this open-field context and have begun work on training matching to sample. Monkeys have been slow to acquire this task, in part because of spatial biases. We are now taking two substantially different approaches in this work, one emphasizing spatial memory and the second emphasizing anticipation of future events. The lab has completed a series of 5 behavioral experiments through this work.