STRATEGIES FOR THE TREATMENT OF HIV ASSOCIATED METABOLIC SYNDROME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 改变生活方式和二甲双胍是可能改善HIV感染患者代谢异常的策略。 在接受联合抗逆转录病毒治疗的HIV感染患者中，符合NCEP-ATP III代谢综合征的定义，其中存在中心性肥胖、代谢异常和炎症增加，我们将检验以下假设： a. 单独改变生活方式和单独使用二甲双胍将改善中心脂肪分布和代谢参数。 B. 与二甲双胍单用相比，生活方式改变单用可更好地改善心血管指数和其他变量。 C. 生活方式改变和二甲双胍联合治疗的策略将比单独改变生活方式或单独使用二甲双胍更能改善心血管、身体组成、炎症和代谢参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lifestyle modification and metformin are strategies that are likely to improve metabolic abnormalities in HIV-infected patients. Among HIV-infected patients treated with combination antiretroviral therapy meeting the NCEP-ATP III definition of metabolic syndrome, in which central adiposity, metabolic abnormalities and increased inflammation are present, we will test the following hypotheses: a. Lifestyle modification alone and metformin alone will result in improved central fat distribution and metabolic parameters. b. Lifestyle modification alone will improve cardiovascular indices and other variables more than metformin alone. c. Strategies of a combination of lifestyle modification and metformin will improve cardiovascular, body composition, inflammatory and metabolic parameters more than lifestyle modification alone or metformin alone.