CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH (CHARTER) EXTENSION

中枢神经系统HIV抗逆转录病毒治疗效果研究（CHARTER）于2002年获得资助，目的是探索在高活性抗逆转录病毒治疗（HAART）的背景下HIV神经系统并发症的变化。CHARTER的六个执行地点（约翰霍普金斯大学、西奈山医学院、加州大学圣地亚哥分校、德克萨斯大学加尔维斯顿分校、华盛顿大学、圣路易斯华盛顿大学）代表了不同的参与者群体以及在神经艾滋病各个方面具有专业知识的研究人员，能够将神经医学、神经心理学、精神病学、神经病变、成像协议以及持续的质量保证程序。CHARTER项目得出的两个关键结论是，尽管有效的艾滋病毒治疗显著降低了死亡率和非神经系统发病率，但艾滋病毒相关神经认知障碍（HAND）和周围神经病变仍然非常普遍。

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) was funded in 2002 with the aim of exploring the changing presentation of HIV neurological complications in the context of highly active antiretroviral therapy (HAART). The six performance sites of CHARTER (Johns Hopkins University, Mt. Sinai Medical School, University of California at San Diego, University of Texas Medical Branch at Galveston, University of Washington, Washington University at St. Louis), representing a diverse participant pool as well as investigators with expertise in various aspects of NeuroAIDS, were able to standardize neuromedical, neuropsychological, psychiatric, neuropathy, and imaging protocols along with on-going quality assurance procedures. Two key conclusions to emerge from the CHARTER project are that HIV-Associated Neurocognitive Disorders (HAND) and peripheral neuropathy remain highly prevalent despite effective HIV treatments that have significantly reduced mortality and non-neurologic morbidities. In CHARTER Extension, 180 participants (30 per site) from the original CHARTER longitudinal cohort have been selected for further study based on the goal of shedding light on CSF virologic failure, low-level HIV replication, worsening cognition and abnormal white matter, as well on-going peripheral neuropathy. These individuals will be assessed annually using well-established neuropsychological, neuromedical, laboratory, and neuropathy assessments. A subset of participants will complete annual brain MRI scans.