Training in Neuroimmune/Neurobehavior Addiction Research

描述（由申请人提供）：这是一份跨学科药物滥用研究培训计划的更新申请，名为神经免疫/神经行为成瘾研究培训（T32 DA007097-30），称为药物神经免疫学。药物神经免疫学培训项目<www.facebook.com/pniprogram b>已经运行了10年，是由明尼苏达大学nida资助的两个项目合并而成的：药物滥用和神经行为药理学培训（T32 DA07097-20）和PNI和药物滥用培训（T32 DA07239-10）。该联合培训项目满足了在跨学科和转化领域培养生物医学科学家的公认需求，该领域专注于药物滥用与神经和免疫系统的相互作用，并将我们对这些生理相互作用与行为对应的理解整合在一起。我们训练这些领域的基础科学家和临床医生进行富有成效的交流。培训计划的一个重要组成部分考虑药物滥用作为艾滋病毒/艾滋病的辅助因素的作用，特别是与神经艾滋病有关。前学员（近10年在读博士25人，博士后22人）在学术界、政府部门、产业界担任重要职务。我们的32位主要教员培训师是明尼苏达大学的一群才华横溢的神经科学家、心理学家、药理学家、免疫学家和微生物学家。在这些学科中，我们有实验室科学家和临床教师，使该项目吸引优秀的学员。我们资金雄厚的教师培训师拥有丰富的导师经验，并致力于在这个跨学科的环境中培养博士生和博士后。我们也有一些具有特定专业知识的共同导师，他们将提供专门的培训内容。为完成我校现有资源的培养任务，现申请10名博士前、5名博士后。成功培训计划的所有要素都已到位，并有效地发挥作用：正式的博士前课程，包括神经免疫相互作用和神经精神药理学课程；两个月一次的系列讨论会；最重要的是，在各个学科的教师之间建立了联系，建立了学院式的、创造性的关系。自上次提交以来，我们在积累经验的基础上实施了两个组成部分，进一步加强了学员的跨学科转化研究经验：1)关于“药物滥用到床边”的临床课程，重点关注海洛因、可卡因/甲基苯丙胺、尼古丁和成瘾的医学并发症，包括艾滋病并发症；2)关于“艾滋病毒/艾滋病：“发病机制、治疗和预防”，由直接治疗艾滋病患者的临床教师领导。

DESCRIPTION (provided by applicant): This is an application for renewal of an interdisciplinary Drug Abuse Research Training Program titled Training in Neuroimmune/Neurobehavior Addiction Research (T32 DA007097-30) known as Pharmaconeuroimmunology. The Pharmaconeuroimmunology Training Program <www.facebook.com/pniprogram> has operated for ten years and resulted from the combination of two previously NIDA-funded programs at the University of Minnesota, Training in Drug Abuse and Neurobehavioral Pharmacology (T32 DA07097-20)" and "Training in PNI and Substance Abuse (T32 DA07239-10)." The combined training program meets a well-recognized need to train biomedical scientists at the pre- and postdoctoral levels in an interdisciplinary and translational field that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts. We train basic scientists and clinicians in these fields to talk to one another productively. A critical component of the training program considers the role of drugs of abuse as co-factors in HIV/AIDS, specifically relating to NeuroAIDS. Former trainees (25 predoctoral and 22 postdoctoral in the past 10 years) hold influential positions in academia, government, and industry. Our 32 primary faculty trainers are a talented group of neuroscientists, psychologists, pharmacologists, immunologists, and microbiologists at the University of Minnesota. Across these disciplines we have both laboratory-based scientists and clinical faculty, allowing the program to attract outstanding trainees. Our well-funded faculty trainers have extensive experience as mentors and are committed to training predoctoral students and postdoctoral fellows in this interdisciplinary setting. We also have co-mentors with selected expertise who will provide specialized training components. To fulfill our training mission with our available resources, we request funding for 10 predoctoral and 5 postdoctoral positions. All of the elements of a successful training program are in place and are functioning efficiently and effectively: a formal predoctoral curriculum, including courses in neuro-immune interactions and neuropsychopharmacology; a bimonthly seminar series; and most importantly, linkages established, collegial, and creative relationships among the faculty across the disciplines. Since the last submission, we have built on our accumulated experience and implemented two components that have further strengthened our trainees' interdisciplinary translational research experiences: 1) a clinical course on "Substance Abuse to the Bedside" that focuses on heroin, cocaine/methamphetamine, nicotine, and the medical complications of addictions, including complications from AIDS, and 2) a new colloquium on "HIV/AIDS: Pathogenesis, Treatment, and Prevention" led by clinical faculty who deal directly with AIDS patients. PUBLIC HEALTH RELEVANCE: This is a competitive renewal for an interdisciplinary training program at the University of Minnesota that focuses on the interactions of drugs of abuse with the nervous and immune systems, and integrates our understanding of these physiological interactions with their behavioral counterparts, including the role of drugs of abuse as co-factors in HIV/AIDS. To fulfill our training mission, 10 predoctoral and 5 postdoctoral positions are requested.