BRAIN AGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在灵长类动物中，人类是独一无二的，易患与年龄有关的神经退行性疾病，特别是阿尔茨海默病，已知这种疾病只在人类中自然发生。 在本报告所述期间，我们探索了人类、黑猩猩（与人类关系最密切的动物）和猕猴（在神经科学研究中经常用作人类模型的灵长类动物）大脑结构年龄相关变化的相似性和差异。 我们使用神经影像学技术，以确定与年龄相关的变化，灰质体积，白色物质的体积，和白色物质的完整性在年轻的成年人，中年人，和老年人的个人，并进行死后显微镜检查的脑组织变化的任何动物在研究过程中死亡。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Humans are unique among primates in their vulnerability to age-related neuro-degenerative disease, especially Alzheimer's disease, which is known to occur naturally only among humans. During the reporting period, we explored similarities and differences in age-related changes in brain structure in humans, in chimpanzees (the animals most closely related to humans), and in macaque monkeys (primates that are often used as models for humans in neuroscientific research). We used neuroimaging techniques to identify age-related changes in gray matter volume, white matter volume, and white matter integrity in young adults, middle-aged adults, and elderly individuals, and carried out postmortem microscopic examination of brain-tissue changes of any animals that died during the course of the study.