MODELING OF HIV BREAST MILK TRANSMISSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 母乳传播艾滋病毒是发展中国家婴儿艾滋病毒/艾滋病的主要原因。值得注意的是，只有少数感染艾滋病毒的母亲所生的母乳喂养婴儿通过母乳接触感染艾滋病毒，这增加了母乳中的免疫因素对未感染的婴儿提供保护的可能性。 我们希望通过研究SIV感染恒河猴模型中的母乳来模拟HIV病毒的进化、细胞嗜性和HIV感染母亲母乳中的免疫反应。 然而，由于在这些研究中使用繁殖雌性恒河猴是不可行的，因此我们优化了一种通过激素操作来诱导泌乳的方案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast milk transmission of HIV is a leading cause of infant HIV/AIDS in the developing world. Remarkably, only a small minority of breastfeeding infants born to HIV-infected mothers contract HIV via breast milk exposure, raising the possibility that immune factors in the breast milk confer protection to the infants who remain uninfected. We wanted to model the HIV viral evolution, cellular tropism and immune responses in breast milk of HIV-infected mothers by studying breast milk in the SIV-infected rhesus macaque model. Since it is however not feasible to use breeder female rhesus monkeys in these studies, we optimized a protocol to pharmacologically induce lactation through hormone manipulation.