Molecular studies of dentine phosphophoryn and development of a biomimetic dental restorative material.

这个项目涉及一种蛋白质的研究，这种蛋白质存在于牙齿中，负责牙质的发育。该项目包括使用各种技术表征这种蛋白质及其与磷酸钙矿物的相互作用。获得的信息将允许合成一种模仿磷酸化蛋白功能的肽。这种肽将与稳定的无定形磷酸钙一起用于一种新的牙齿修复材料，这将有助于保护周围的牙齿组织。结果将是一个更好的理解设计原则使用的自然工程牙齿。其意义在于开发具有生物相容性的优质牙体修复材料的潜力。

This project involves the study of a protein that is found in teeth and is responsible for the development of dentine. The project involves characterisation of this protein and its interaction with calcium phosphate mineral using a variety of techniques. The information obtained will allow the synthesis of a peptide that will mimick the function of phosphophoryn. This peptide will be used together with stabilized amorphous calcium phosphate in a novel dental restorative material that will help protect the surrounding tooth tissue.The outcome will be an improved understanding of the design principles used by nature to engineer teeth. The significance is the potential development of biocompatible, superior dental restorative materials.