UC Davis Environmental Health Sciences Core Center

 描述(由申请人提供) 加州大学戴维斯分校中心“环境暴露、机制和疾病的发展”的中心主题是确定暴露途径和疾病机制，以加深对环境暴露如何威胁人类健康的理解，并制定减轻其影响的策略。该中心汇集了来自四所学校和大学的19个系的教员，从事与人类状况相关的环境健康科学(EHS)研究，涉及分子机制、暴露科学、病理生理学和流行病学。该中心将通过以下方式显著扩展加州大学戴维斯分校的EHS研究：1)推进尖端科学，2)扩大EHS研究人员队伍，3)与政策制定者、倡导组织和卫生专业人员接触，以确保我们研究的相关性，并将研究结果转化为公共卫生改善。EHS核心中心将建立在EHS独立资助的一大批教师的基础上，促进协同合作，并产生新的科学突破，如果没有该中心将提供的互动和整合机会，就不可能发生新的科学突破。该中心将培训年轻的研究人员，并吸引以前没有在EHS工作的教师，他们将他们的技能和技术带到EHS研究中。在EHS主要优势的基础上，四个主要主题领域是：环境诱导对神经系统的影响，2)呼吸，3)免疫，4)内分泌或代谢功能。感兴趣的暴露包括环境空气中的一系列颗粒和挥发性有机污染物化合物，以及饮用水、食品和家用或个人护理产品中的污染物。中心领导层将征求外部科学咨询委员会、内部执行咨询委员会和社区利益相关者咨询委员会的意见。组织结构包括行政核心、职业发展方案、试点项目方案、曝光核心、综合健康科学核心以及社区外联和参与核心。

 DESCRIPTION (provided by applicant) The central theme of the University of California Davis Center "Environmental Exposures, Mechanisms, and the Development of Disease" is the identification of exposure pathways and disease mechanisms in order to deepen understanding of how environmental exposures threaten human health and to develop strategies to mitigate their effects. This Center brings together faculty from 19 departments in four schools and colleges engaged in environmental health sciences (EHS) research spanning molecular mechanisms, exposure science, pathophysiology, and epidemiology, with relevance to human conditions. The Center will markedly expand UC Davis EHS research at UC Davis by: 1) advancing cutting-edge science, 2) enlarging the cadre of EHS researchers, and 3) engaging with policy-makers, advocacy organizations and health professionals, to ensure relevance of our research and to translate findings into public health improvement. This EHS Core Center will build upon a critical mass of faculty independently funded in EHS, facilitate synergistic collaborations and generate novel scientific breakthroughs unlikely to occur without the opportunities for interaction and integratio this Center will provide. The Center will train young investigators and attract faculty previously not working in EHS who bring their skills and technologies to EHS research. Building on the major EHS strengths, the four primary thematic areas are: environmentally-induced effects on 1) nervous system, 2) respiratory, 3) immune, and 4) endocrine or metabolic function. Exposures of interest include an array of particles and volatile organic contaminant compounds in ambient air, and pollutants in drinking water, in food and from household or personal care products. Center leadership will solicit input from an External Science Advisory Committee, an Internal Executive Advisory Committee, and a Community Stakeholder Advisory Committee. The organizational structure includes an Administrative Core, a Career Development Program, a Pilot Projects Program, an Exposure Core, an Integrative Health Sciences Core, and a Community Outreach and Engagement Core.