Childhood Leukemia International Consortium Scientific Annual Meetings

 描述（由申请人提供）：儿童白血病国际联盟（CLIC）成立于2007年，是一组独立的国际研究人员，他们研究环境，遗传，感染和临床风险因素在儿童白血病病因学中的作用，并分享病例对照和基于家庭的三重研究的数据。CLIC包括来自全球17个国家的33项儿童白血病病例对照研究（25名主要研究者），代表约20，000例病例和200，000例对照。大约90%的研究有全面的流行病学数据，大约一半有生物标本。CLIC正在扩大其研究组合，以包括白血病以外的儿童癌症，这将使该联盟能够汇集其他16种儿童癌症的资源和数据（例如，12项颅内肿瘤研究，11项星形细胞瘤研究，10项室管膜瘤研究，8项髓母细胞瘤研究，9项其他胶质瘤研究，9项霍奇金和非霍奇金淋巴瘤研究等）。 虽然CLIC成员全年都参加电话会议，但每年的成员面对面会议对于规划和评估合作研究项目的进展以及讨论新的研究方向至关重要。接下来的三次CLIC年会（2015-2017）将为继续讨论和增加成员的知识基础提供一个论坛。它还将实现以下目标： * 计划并实施儿童白血病的遗传学和基因-环境的合并和验证研究;讨论未来的表观遗传学研究。 * 讨论扩大CLIC，以包括其他儿童癌症，特别是脑肿瘤，这将利用我们现有的基础设施，合议关系和知识;评估当前的文献，以确定CLIC可以最好地贡献的研究差距。 * 识别和解决方法上的挑战，如可能的选择和回忆偏差的影响，因果推理的统计方法的应用。 * 与领先的国家卫生研究所合作，以确定对代表性不足的癌症儿童的潜在研究;鼓励参与并增加来自中美洲和南美洲以及亚洲的代表性不足的人口的成员。 * 讨论并确定最适合量化研究翻译、研究传播和与利益相关者沟通的研究领域。

 DESCRIPTION (provided by applicant): The Childhood Leukemia International Consortium (CLIC), established in 2007, is a group of independent, international researchers who study the role of environmental, genetic, infectious, and clinical risk factors in the etiology of childhood leukemia and who share data from case-control and family-based trio studies. CLIC includes 33 childhood leukemia case-control studies worldwide from 17 countries (25 Principal Investigators) representing approximately 20,000 cases and 200,000 controls. Approximately 90% of the studies have comprehensive epidemiologic data, and about half have biospecimens. CLIC is expanding its research portfolio to include childhood cancers other than leukemia, which will enable the Consortium to pool resources and data across 16 other childhood cancers (e.g., 12 studies on intracranial tumors, 11 studies on astrocytoma, 10 studies on ependymomas, 8 studies on medulloblastomas, 9 studies on other gliomas, and 9 studies on both Hodgkin and non-Hodgkin lymphomas, etc.). Though CLIC members participate in teleconferences throughout the year, the annual in-person meeting for members is essential for planning and evaluating progress on collaborative research projects, and discussing new research directions. The next three CLIC annual meetings (2015-2017) will provide a forum for continuing discussions and increasing the knowledge base of members. It will also achieve the following goals: * Plan and conduct genetic and gene-environment pooled and validation studies in childhood leukemia; discuss future epigenetic studies. * Discuss expanding CLIC to include other childhood cancers, especially brain tumors, which will take advantage of our existing infrastructure, collegial relationships, and knowledge; evaluate current literature to identify gaps in research where CLIC can best contribute. * Identify and address methodological challenges such the impact of possible selection and recall bias, application of statistical methods for causal inference. * Partner with leading national institutes of health to identify potential studies of under-represented children with cancers; encourage participation and increase membership of under-represented populations from Central and South America and Asia. * Discuss and identify research areas most suitable for quantitative research translation, research dissemination and communication to stakeholders.