University Training Program in Biomolecular and Tissue Engineering

描述(由申请人提供)：目前的提案寻求更新杜克大学生物分子和组织工程(BTE)方面的NIGMS生物技术培训计划。BTE生物技术培训计划的目标是在生物分子、细胞和组织的设计、操作和定量表征方面提供课堂、实验室和研究方面的博士前培训。BTE的培训计划包括来自普拉特工程学院(生物医学工程、土木和环境工程、机械工程和材料科学)的31名培训教师和17名教师，以及来自非工程领域的14名教师。在非工程学的BTE教员中，有5人在三一文理学院(化学、计算机科学)，9人在基础医学(细胞生物学、放射肿瘤学、外科、生物信息学、医学、眼科和放射学)和杜克大学医学中心的临床系(妇产科、内科、病理学、放射肿瘤学、放射学、外科)。在NIGMS支持的17年中，共有68名学生获得了BTE的博士前实习生职位：42名实习生获得了博士学位，18名学员仍在培训中，7名学员退出了该项目。这个 受训人员的专业分类为BME 47人，ME和MS 10人，化学7人，生化工程、电气工程、细胞生物学、动物学、生物信息学和基因组技术各1人。BTE博士前实习生被要求(1)进行跨学科性质并对医学生物技术的发展至关重要的研究，(2)在其博士论文委员会中至少有两名BTE教员，(3)选修三门经批准的基于实验室的现代生物技术工程课程之一，(4)选修四门提供BTE广度的工程选修课[来自非工程学科的受训者选择两门工程选修课]，(5)选修两门与BTE相关的生物医学科学高级课程，(6)参加跨学科“BioE”系列研讨会的两个学期的学分，(7)参加为期三个月的工业生物技术实习；(8)出席BTE年度海报会议；(9)接受负责任的研究行为培训。BTE培训补助金目前支持9名研究员，从研究生学习的第一年或第二年开始，为期两年。我们要求维持这一水平的支持。

DESCRIPTION (provided by applicant): The current proposal seeks renewal of the NIGMS biotechnology training program in Biomolecular and Tissue Engineering (BTE) at Duke University. The objective of the biotechnology training program in BTE is to provide classroom, laboratory, and research predoctoral training in the design, manipulation, and quantitative characterization of biomolecules, cells and tissues. The training program in BTE involves 31 training faculty with 17 faculty from the Pratt School of Engineering (Biomedical Engineering, Civil & Environmental Engineering, Mechanical Engineering & Materials Science) and 14 faculty from non-engineering fields. Of the non-engineering BTE faculty, 5 are in the Trinity College of Arts & Sciences (Chemistry, Computer Science), and 9 in the Basic Medical Science (Cell Biology, Radiation Oncology, Surgery, Bioinformatics, Medicine, Ophthalmology, and Radiology) and Clinical Departments of the Duke University Medical Center (Obstetrics & Gynecology, Medicine, Pathology, Radiation Oncology, Radiology, Surgery). Over the 17 years of NIGMS support, a total of 68 students have received predoctoral traineeships in BTE: 42 trainees have received their doctorates, 18 are still in training, and 7 have left the program. The disciplinary breakdown of trainees is 47 in BME, 10 in ME&MS, 7 in Chemistry, and 1 each in Biochemical Engineering, Electrical Engineering, Cell Biology, Zoology, and Bioinformatics & Genome Technology. BTE predoctoral trainees are required to (1) perform research that is interdisciplinary in nature and is central to the development of medical biotechnology, (2) have at least two BTE faculty on their doctoral dissertation committee, (3) take one of three approved laboratory-based engineering courses in modern biotechnology, (4) take four engineering electives that provide breadth in BTE [trainees entering the program from non-engineering disciplines select two engineering electives], (5) take two advanced courses in the biomedical sciences relevant to BTE, (6) take two semesters of the interdisciplinary "BioE" seminar series for credit, (7) participate in a three-month industrial biotechnology internship, (8) present in th annual BTE poster session, and (9) undergo training in responsible conduct in research. The BTE training grant currently supports 9 fellows for two years commencing in either the first or second year of graduate study. We request that this level of support be maintained.