Mutations in ubiquitin proteasome pathway genes as a cause of frontotemporal dementia and motor neuron disease

该项目旨在确定受痴呆症和运动神经元疾病影响的家庭中发生突变的基因，并确定相同的基因是否导致大量患有类似疾病的患者的疾病。识别这些基因将揭示哪些生物过程会导致大脑和神经细胞退化，为全球许多受这些疾病影响的人开发新的治疗方法提供重要知识。

This project aims to identify genes that are mutated in families affected with dementia and motor neuron disease, and to determine whether the same genes are responsible for disease in large collections of patients with similar disorders. Identifying these genes will reveal what biological processes can lead to brain and nerve cell degeneration, providing knowledge important for development of new treatments for the many people worldwide affected with these disorders.