University of Florida Older Americans Independence Center (OAIC)

项目摘要 佛罗里达大学老年美国人独立中心(OAIC)的使命有两个：1)优化 通过跨学科方法促进老年人的身体表现和行动能力 独立性；以及2)培训早期研究人员进行老龄化和残疾研究，同时发展其 领导力品质。我们的目标是提高晚年的健康和独立性，特别注重行动能力。 为了完成我们的使命，我们的战略是吸引来自不同行为、 具有共同研究重点的临床、基础和技术科学学科 和独立性。“遍及包括分子生物学在内的整个生物医学研究领域， 动物研究、临床研究、行为科学、流行病学、数据科学、人工智能和 工程，我们的研究努力满足了OAIC的总体目标：增加科学知识，使 以更好的方式维持或恢复老年人的独立性。我们的研究目标是：1)评估， 利用老年学和翻译研究，生物、共病、心理社会、环境、 行为、认知和其他因素，导致认知和身体功能下降，行动不便， 和丧失独立性；以及2)在临床和临床前研究中开发并可靠地测试干预措施 以行动能力为目标，防止、延缓或恢复与年龄相关的身体和认知功能下降。我们的 教育目标是培养未来老年临床转化研究的领导者。为了满足这些要求 目标拟议的OAIC培训研究教育核心(REC)学者并支持研究人员， 资源、服务、外部研究、发展项目和试点/探索性研究 集成核心： ·领导和行政核心(LAC)； ·研究教育核心(REC)； ·试点/探索性研究核心(PESC)； ·临床研究核心(RC1)； ·新陈代谢和翻译科学核心(RC2)； ·生物统计核心(RC3)；以及 ·数据科学和应用技术核心(RC4)。 在这次更新的OAIC申请中，我们将增加丰富的专业知识和卓越的业绩记录 目前的筹资周期取得了成功。OAIC的一项相关力量是 跨学科核心、项目和研究人员，致力于一个共同的研究重点 生物医学研究领域。

Project Summary The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons’ physical performance and mobility through interdisciplinary approaches to promote independence; and 2) to train early stage investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus on “promotion of mobility and independence.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, data science, artificial intelligence, and engineering, our research effort addresses the OAIC’s general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using geroscience and translational research, the biological, co-morbid, psychosocial, environmental, behavioral, cognitive, and other factors that contribute to cognitive and physical function decline, loss of mobility, and loss of independence; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical and cognitive function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Research Education Core (REC) Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: • Leadership and Administrative Core (LAC); • Research Education Core (REC); • Pilot/Exploratory Studies Core (PESC); • Clinical Research Core (RC1); • Metabolism and Translational Science Core (RC2); • Biostatistics Core (RC3); and • Data Science and Applied Technology Core (RC4). In this renewal OAIC application we will augment the wealth of expertise and remarkable track record of success of the current funding cycle. A relevant strength of our OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.