Cerebrovascular Research Training Program

描述（由申请人提供）：本提案是一个新的高度集中的脑血管疾病博士后培训计划，将在西奈山医学院和西奈山中风和医疗中心生物科学研究生院的神经病学，神经外科，神经科学和急诊医学系开展。非常强大的跨部门和多学科的合作得到了培养和巩固，来自NIH的校外资金呈指数级增长。基于一个肥沃的和不断扩大的研究存在与一个既定的，积极的和有竞争力的培训组成部分，我们寻求正规化的研究培训和下一代的医生和研究科学家的职业发展，在这个竞技场的证明实力在这些部门。我们已经采取了多个具体步骤，以确保临床和基础教师导师之间的凝聚力计划。我们的建议是及时的，因为中风引起的疾病负担巨大，而且随着人口老龄化，中风的流行越来越严重。此外，由于西奈山服务于一个三种族社区，少数民族经历了不成比例的中风，它准备吸引少数民族申请人有兴趣推进少数民族中风的医疗保健问题。在脑血管计划和神经保护计划的广度和深度内，博士后学员（M.D.s和/或Ph.D.s）将获得一个出色的指导，单独制作的环境（10名NIH资助的导师），他们可以沉浸在基础/教学课程工作中，包括儿科脑血管疾病，实验设计和方法以及其他研究技术（例如，赠款写作，道德行为）批判性地应用于研究的主要基础或临床研究领域。博士后学员将受到密切监督和指导，以便能够通过结构化的互动环境过渡到独立的，基础的或临床的神经科学家。重点是独立研究，展示思维能力，批判性推理，科学写作和演示以及协作。通过积极的招聘战略，包括关注少数民族申请人，研究员将接受为期2-3年的培训。我们希望招募具有研究经验但对脑血管疾病/神经保护/细胞死亡知识有限的博士，以及寻求密集的、高水平的以医学为导向的研究培训的医学博士（临床训练过的神经学家、神经外科医生和急诊医学医生），使他们能够成功地作为未来的研究者竞争。我们也会招募医学博士-博士们准备把他们的综合技能集中在一个特定的常见的，致残的神经系统疾病上。该计划将由Levine博士（主任），一位经验丰富，成功的导师和研究人员以及一个精心挑选的执行委员会管理。我们将提供培训和经验以及定制的咨询委员会，使博士后研究员在完成我们的计划后成为独立和成功的研究人员。由于中风是美国第三大死亡原因，也是成人残疾的头号原因，因此中风仍然是当今美国的主要公共卫生问题之一。尽管如此，以及美国人口的老龄化，该国很少有政府指定的中风研究培训计划。我们的建议将增加一个中风培训计划，重点是准备下一代中风研究人员通过在一个优秀的研究和培训环境中的临床和基础研究的几个途径来解决中风的问题。

DESCRIPTION (provided by applicant): This proposal is for a new highly focused postdoctoral training program in cerebrovascular disease that will be based in the Departments of Neurology, Neurosurgery, Neuroscience, and Emergency Medicine at The Mount Sinai Schools of Medicine and Graduate School of Biological Sciences within the Mount Sinai Stroke and Medical Centers. Very strong interdepartmental and multi-disciplinary collaborations have been fostered and solidified, and extramural funding from the NIH has grown exponentially. Based on a fertile and expanding research presence with an established, active and competitive training component, we seek to formalize the research training and career development of the next generation of physician and research scientists in this arena of proven strength within these departments. We have taken multiple concrete steps to insure a cohesive program among the clinical and basic faculty mentors. Our proposal is timely given the tremendous burden of illness stroke causes and the growling epidemic of stroke as the population ages. Further, as Mount Sinai serves a tri-racial community, with minorities experiencing a disproportionate share of stroke, it is poised to attract minority applicants interested in advancing minority health-care issues in stroke. Within the breadth and depth of the cerebrovascular program and the neuroprotection programs, postdoctoral trainees (M.D.s and/or Ph.D.s) will be given an outstanding mentored, individually crafted milieu (10 NIH-funded mentors) where they can immerse in basic/didactic course work, including pediatric cerebrovascular disease, experimental design and methodology and other research techniques (e.g. grant writing, ethical conduct) critically applied to either primarily basic or clinical investigative areas of research. Postdoctoral trainees will be closely supervised and mentored to be able to transition to an independent, basic or clinical neuroscientist through a structured, interactive environment. The focus is on independent research, demonstrating skills of thought, critical reasoning, scientific writing, and presentations, and collaboration. With active recruiting strategies, including attention to minority applicants, fellows will train for a period of 2-3 years. We anticipate recruiting Ph.D.s with research experience but with limited knowledge of cerebrovascular diseases/neuroprotection/cell death, and M.D.s (clinically trained neurologists, neurosurgeons, and emergency medicine physicians) seeking intensive, high-level translational-oriented research training allowing them to compete successfully as future investigators. We will also recruit M.D.-Ph.D.s ready to focus their combined skills towards a specific common, and disabling neurological disease. The program will be administered by Dr. Levine (Director), an experienced and successful mentor and researcher and a carefully chosen Executive Committee. We will provide the training and experience and a customized Advisory Committee that will allow postdoctoral fellows to become independent and successful investigators upon completion of our program. As stroke is the third leading cause of death in America and the number one cause of adult disability, stroke remains one of the major public health problems in the United States today. Despite this, and the aging population of America, there are very few government-designated training programs in stroke research in the country. Our proposal would add a stroke training program that will focus on preparing the next generation of stroke researchers to tackle the problem of stroke via several avenues of clinical and basic research within an outstanding research and training environment.