Clinical Research Center for REstoration of NEural-based Function in the Real World (RENEW)

项目总结/摘要 南卡罗来纳州医科大学的RENEW中心将是一个独特的临床研究机构 致力于在真实的世界中恢复基于神经的功能-这是南方唯一的此类设施。 卡罗莱纳。该中心的目标是：1）建造一个即将建成的健康学院的两层楼 位于MUSC校园中心的热电联产（CHP）大楼。RENEW中心装修将完成 与新的热电联产建设同时进行，并将满足绿色地球2认证。2)建立这一 专门设施，用于促进对支持身体和心理社会的神经回路的深入理解 功能及其在损伤、疾病、发育或衰老后的恢复，为以下方面提供机制基础： 旨在影响真实的世界中的功能的干预措施。这与MUSC研究直接一致 三个领域的战略计划：神经回路和神经调节;老龄化;远程医疗。3)开发一个 一个跨学科的研究计划，重点是开发干预措施，改变功能在真实的世界 (vs.理想的实验室环境）聚集神经外科医生，神经学家，精神病学家，神经心理学家， PT、言语治疗师、OT、运动科学家、工程师和其他共同目标是减少 全国残疾人。作为一个新兴的卓越机构，MUSC致力于大量的研究， 在过去十年中，培训资源，以满足中风和其他疾病患者的迫切需求， 减少少数民族和农村人口的健康差距。RENEW将建立在这些基础之上 投资在生态有效的环境中进行神经回路功能研究，这是前所未有的。 可能在MUSC。RENEW分为四个研究集群：神经功能集群， 理解，记录和调节神经回路;开发和研究的身体功能群 康复干预;心理社会功能集群，以发展和研究行为健康 干预措施;以及创新和技术集群，以实现远程干预，评估和 在参与者的生活环境中进行监测。指导RENEW中心发展的一个新信念是， 许多目前的干预措施缺乏持久性，并且在家庭中对功能状态的影响小于在诊所中 因为缺乏综合的身体和行为干预措施来解释人们如何改变他们的行为， 生活环境中的行为。C 06将使整个大学的MUSC利益相关者从三个 学院和16个部门建立RENEW中心，提供基础设施，实验室和人力资本 在影响在册种姓居民的身体和心理功能以及独立性方面具有独特的地位。 尊敬、教育、培养和赋权于妇女组织将凝聚大量多学科的身体康复和行为健康 研究人员在一个中央，专门的设施，并提高他们的专业知识，在真实的世界翻译研究。 如果没有这些独特的资源， 环境将大大减少--特别是对我们相当大的农村人口和得不到充分服务的人口。

PROJECT SUMMARY / ABSTRACT The RENEW Center at the Medical University of South Carolina (MUSC) will be a unique clinical research facility dedicated to the restoration of neural-based function in the real world – the only such facility of its kind in South Carolina. The center goals are to: 1) Build out two floors of a soon-to-be constructed College of Health Professions (CHP) building in the heart of the MUSC campus. The RENEW Center upfit will be completed concurrently with the new CHP building construction and will meet Green Globes 2 certification. 2) Establish this specialized facility for advancing deep understanding of the neural circuits supporting physical and psychosocial function and their recovery after injury, disease, development, or aging to provide a mechanistic basis for interventions designed to impact functioning in the real world. This aligns directly with the MUSC Research Strategic Plan in three areas: Neural Circuits & Neuromodulation; Aging; Telehealth. 3) Develop an interdisciplinary research program that focuses on developing interventions that change function in the real world (vs. ideal lab settings) by gathering together neurosurgeons, neurologists, psychiatrists, neuropsychologists, PTs, speech therapists, OTs, exercise scientists, engineers, and others with a shared goal of decreasing disability statewide. As an Institution of Emerging Excellence, MUSC has dedicated considerable research and training resources over the past decade to meet the urgent needs of those living with stroke and other conditions, and to reducing health disparities in minority and rural populations. RENEW will build on these foundational investments to conduct neural circuit function research in ecologically valid environments that never before has been possible at MUSC. RENEW is organized into four research clusters: a Neural Function Cluster to understand, record from, and modulate neural circuits; a Physical Function Cluster to develop and study rehabilitation interventions; a Psychosocial Function Cluster to develop and study behavioral health interventions; and an Innovation & Technology Cluster to enable remote intervention, assessments, and monitoring in participants’ lived environments. A novel belief that guided RENEW Center development is that many current interventions lack durability and affect less change in functional status in the home than in the clinic because of a lack of integrated physical and behavioral interventions that account for how people change their behavior in their lived environment. The C06 will enable MUSC stakeholders across the university from three colleges and 16 departments to establish the RENEW Center with the infrastructure, labs, and human capital uniquely positioned to impact the physical and psychosocial functioning and independence of SC residents. RENEW will coalesce a critical mass of multidisciplinary physical rehabilitation and behavioral health investigators within a central, specialized facility and enhance their expertise in real world translational research. Without these unique resources, the positive and lasting functional impacts on SC residents in their lived environments would be dramatically reduced – especially for our sizeable rural and underserved populations.