COllaborative research, implementation, And LEadership training to addresS chronic Conditions across the lifecoursE (COALESCE)

数据摘要/摘要 慢性心脏代谢（糖尿病、心血管疾病）和神经精神疾病（认知和 精神健康障碍）是低收入和中等收入国家迅速增长的公共卫生问题 （LMIC）。印度和埃塞俄比亚等中低收入国家正在经历慢性病的上升， 营养不良和环境污染的残余负担。中低收入国家对慢性疾病的反应是 由于研究能力有限。我们建议解决研究和实施方面的不足 在印度和埃塞俄比亚的慢性疾病的能力。来自埃默里大学的团队（Ali，项目总监 [PD])，印度慢性病控制中心（Prabhakaran，co-PD）和阿迪斯亚的斯亚贝巴大学， 埃塞俄比亚（Mariam，共同PD）共同设计了“合作研究、实施和领导力培训”项目， 解决整个生命过程中的慢性病”（COALESCE）计划。我们从两个以前的 成功的培训计划和增加的关键创新。在可持续的国内研究方面取得进展 在培训方面，我们将为12名中期研究人员提供导师培训，以发展国内能力， 对年轻研究人员进行有效指导。此外，以前的D43计划校友将参加 指导培训并担任COALESCE学员的研究导师。这种方法利用了以前的 投资，并提供职业发展和支持，为以前的学员在新的导师角色。我们将 然后每年招募并培训四批博士后学员，每批六名（印度和埃塞俄比亚各三名） （共n=24）在18个月的研究金。该奖学金包括在埃默里大学学习两个月， 课程，参与美国研究文化，并制定项目概念;在接下来的16个月里，学员 将在国内和美国导师的指导下完成本国的项目。我们将促进一个 对整个生命过程中慢性病的综合观点，并将受训者与资源联系起来（例如， 队列研究，附属中心），内容广泛，方法专业。加强我们 我们将成功举办关于实施的年度短期课程 科学和领导力，可以培养组织管理技能。加快翻译速度， 执行证据付诸实践，我们将开启执行科学和领导课程， 处于预防和控制第一线的公共卫生、政府和临床从业人员（n=80） 计划和政策执行。研究人员和从业人员的共同参与将直接将这些 通常是孤立的利益相关者，并促进合作。我们将利用埃默里大学的长期优势 在印度和埃塞俄比亚建立伙伴关系，并为南南合作提供机会。述合并 该计划旨在通过提供津贴，当地指导， 在现有平台中嵌入实习生项目，并激发生产力文化。该计划渴望 促进当地驱动的研究，以塑造慢性病的优先事项，做法，计划和政策。

PROGRAM SUMMARY / ABSTRACT Chronic cardio-metabolic (diabetes, cardiovascular diseases) and neuropsychiatric conditions (cognitive and mental health disorders) are rapidly growing public health problems in low- and middle-income countries (LMIC). LMICs such as India and Ethiopia are experiencing rising chronic diseases while still contending with residual burdens of under-nutrition and environmental pollution. Responses to chronic conditions in LMICs are constrained by limited research capacity. We propose to address shortages in research and implementation capacity for chronic conditions in India and Ethiopia. Teams from Emory University (Ali, Program Director [PD]), the Center for Chronic Disease Control, India (Prabhakaran, co-PD), and Addis Ababa University, Ethiopia (Mariam, co-PD) co-designed the “COllaborative Research, Implementation, And LEadership Training to AddresS Chronic Conditions across the Life CoursE” (COALESCE) program. We draw from two previous successful training programs and added key innovations. To progress towards sustainable in-country research training, we will provide mentor training to 12 mid-stage researchers to develop in-country capacity for more effective mentoring of young researchers. Moreover, prior D43 program alumni will be participants of the mentor training and serve as research mentors for COALESCE trainees. This approach capitalizes on previous investments and provides career advancement and support for previous trainees in new mentor roles. We will then recruit and train four cohorts of six post-doctoral trainees (three each from India and Ethiopia) annually (total n=24) in an 18-month fellowship. The fellowship includes two months at Emory University to complete coursework, engage in US research culture, and develop project concepts; over the next 16 months, trainees will complete projects in their home country with guidance from in-country and US mentors. We will promote an integrated perspective of chronic conditions across the life course, and connect trainees with resources (e.g., cohort studies, affiliated centers) with wide-ranging content and methodological expertise. To strengthen our partner LMIC institutions from within, we will deliver our successful annual short-course on implementation science and leadership that can cultivate organizational management skills. To accelerate translation and implementation of evidence into practice, we will open the implementation science and leadership course to public health, government, and clinical practitioners (n=80) that are on the frontline of prevention and control program and policy implementation. Jointly engaging researchers and practitioners will directly connect these usually siloed stakeholders and promote collaboration. We will leverage Emory University's longstanding partnerships in India and Ethiopia and open opportunities for South-South collaboration. The COALESCE program is designed to promote high in-country retention of trainees by providing stipends, local mentorship, embedding trainee projects in existing platforms, and motivating a culture of productivity. The program aspires to facilitate locally-driven research to shape chronic disease priorities, practices, programs, and policies.