Tissue Resource and Morphology Core (TRMC)

摘要： 组织培养和动物模型的结果提供了重要的信息，但必须在人体中验证 认为具有临床相关性的组织。因此，这个奥布莱恩中心的成功将取决于 获得高质量、适当选择的人体组织标本。组织资源和 Morphology Core（TRMC）将提供此类材料。TRMC将基于健康科学组织 Bank是一家核心机构，15年来一直从BPH患者身上获取前列腺组织。主任 健康科学组织库的Rajiv Dhir博士，一位经过泌尿生殖系统培训的委员会认证病理学家， 病理学，将担任TRMC主任。Dr. Dhir将确保BPH的正确使用和分析 建议项目中的样本。TRMC将提供一系列服务：（1）采购正常的 以及患病的前列腺和膀胱;（2）样本库;（3）数据收集以注释样本， 样本数据输入和库存管理;（4）形态学支持，用于为 建议的研究;（5）组织学支持和免疫组织化学。组织微阵列的发展将是 如果需要的话，进行高通量评估。(6)支持和协助机构审查委员会 问题.

Abstract: Results from tissue culture and animal models provide important information, but must be validated in human tissue to be considered clinically relevant. Thus, the success of this O'Brien Center will depend upon the availability of high quality, appropriately selected human tissue specimens. The Tissue Resources and Morphology Core (TRMC) will supply such material. The TRMC will be based on the Health Sciences Tissue Bank, a core facility that has been accruing prostate tissue from BPH patients for over 15 years. The Director of the Health Sciences Tissue Bank, Dr. Rajiv Dhir, a board certified pathologist with training in genitourinary pathology, will serve as the TRMC Director. Dr. Dhir will assure the proper use and analysis of BPH specimens in the proposed projects. The TRMC will provide an array of services: (1) Procurement of normal and diseased prostates and bladders; (2) Banking of specimens; (3) Data collection to annotate samples, specimen data entry, and inventory management; (4) Morphology support for appropriate case selection for the proposed studies; (5) Histology support and immunohistochemistry. Tissue microarray development will be done for high throughput assessment, if needed. (6) Support and assistance for Institutional Review Board issues.