Mitochondrial regulation and function in cancer and cardiovascular biology

我们的实验室对p53的生物学感兴趣，重点是它对代谢的调节以及它如何影响癌症和心血管生物学。为此，我们正在研究Li-Fraumeni综合征（LFS），这是一种由TP53基因种系突变引起的早发性癌症疾病，使用小鼠模型和涉及LFS患者的转化研究。到目前为止，我们的研究已经产生了一些见解，这些见解可能有助于制定预防癌症和维持心血管健康的新策略。我们正在计划一项更大的转化研究，作为NIH内部和外部研究人员之间的合作项目，研究二甲双胍在LFS患者化学预防中的使用。我们还创建了两个新的基于人类突变的LFS小鼠模型，以了解它们的生物学。

Our laboratory is interested in the biology of p53 with a focus on its regulation of metabolism and how this can impact cancer and cardiovascular biology. To this end, we are studying Li-Fraumeni syndrome (LFS), an early onset cancer disorder caused by germline mutations in the TP53 gene, using both mouse models and translational studies involving LFS patients. Our investigations to date have yielded insights that may be useful for developing new strategies for preventing cancer and maintaining cardiovascular health. We are in the process of planning a larger translational study examining the use of metformin for chemoprevention in LFS patients as a collaborative project between NIH intramural and extramural investigators. We have also created two new LFS mouse models based on human mutations to understand their biology.