International Herpesvirus Workshop

项目摘要 这项提案要求资金用于支持博士后研究员的旅费和注册费，并 研究生参加在德国柏林举行的第45届国际疱疹病毒研讨会(IHW)。IHW是 科学家研究所有疱疹病毒的主要年度会议，并在第45届会议上非常有地位 年。这次会议非常成功，部分原因是世界各国的热情参与。 领先的疱疹病毒研究人员。研讨会的优势在于从以下方面产生的交叉受精 比较不同的疱疹病毒、解决关键问题的不同方法以及对 该领域领先研究人员的参与，最重要的是包括有前途的年轻研究人员和 正在训练的学生。此外，该论坛具有真正的国际性，出席者基础广泛，遍及世界各地。这个 这次会议的医学重要性从现在引起的各种疾病中清楚地表明出来- 识别出八种人类疱疹病毒。这些疾病包括皮肤和眼睛溃疡(HSV-1)、生殖器病变(HSV-1)。 )、脑膜炎和脑炎(HSV-1和HSV-2)、传染性单核细胞增多症(EBV)、水痘和带状疱疹 (VZV)。巨细胞病毒是导致出生缺陷的主要原因，包括智力低下、失明和耳聋，原因是 先天性传播也是艾滋病患者和器官移植的重要机会性病原体 收件人。此外，巨细胞病毒也被认为是致病因素之一。 动脉硬化。癌症也与疱疹病毒感染有关。EB病毒与伯基特病有关 淋巴瘤、其他B细胞肿瘤和鼻咽癌。最新的人类疱疹病毒 发现的(HHV-8或KSHV)与艾滋病患者和其他人的卡波西肉瘤有关 其他组免疫抑制者。所有的疱疹病毒都会持续一生，因此会 免疫受损个体的治疗中存在的重大问题。因重新激活而引起的疾病 大多数人类疱疹病毒是各种免疫患者发病和死亡的重要原因 人口。研讨会将对以下主题采取跨学科的方法：病毒结构， 病毒进入和细胞间传播的机制，膜蛋白，发病机制和潜伏期，DNA复制， 疫苗接种与免疫反应、转录调控、基因表达调控、化疗 靶点和病毒基因疗法。

Project Summary This proposal requests funds to be used to support travel and registration fees for postdoctoral fellows and graduate students to attend the 45th International Herpesvirus Workshop (IHW) in Berlin, Germany. The IHW is the major annual meeting for scientists studying all the herpesviruses and is very well established in its 45th year. This meeting has been very successful, in part, because of the enthusiastic participation of the world’s leading herpesvirus researchers. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpesviruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based world-wide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now- recognized eight human herpesviruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV- 2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. In addition, CMV has been implicated as a pathogenic contributor in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt’s lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi’s sarcoma in AIDS patients and other immunosuppressed persons in other groups. All of the herpesviruses persist for life and therefore pose significant problems in the treatment of immune-compromised individuals. Diseases caused by reactivation of most human herpesviruses are a significant cause of morbidity and mortality in various immune patient populations. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy.