fMRI and treatment response with binge drinking adolescents

项目摘要 虽然转化研究领域正在获得越来越多的关注，但很少有团队成功地整合了 大脑+行为的方法来检查青少年大脑发育的成瘾治疗的背景下。 PI Feldstein Ewing一直站在这项工作的最前沿，他强调，与成年人相比， 成瘾治疗期间中皮质边缘区奖励反应减少，青少年成瘾 行为改变围绕着增强的默认模式网络反应[DMN;楔前叶，后 扣带回（PCC）和额中回（MFG）]。我们的基础研究强调，在这个年龄组， 在治疗的关键要素（客户语言;治疗师语言）期间， 更大的行为改变（更少的问题饮酒）。我们的基础研究也取得了重大进展 神经发育成瘾理论，阐明了青少年成瘾的4个神经生物行为驱动因素 治疗反应，包括创新的行为治疗方法，有计划地整合 神经发育的观点和参与：（a）亲社会（与问题为基础）的方法，（B）青少年的 急剧发展的认知技能，（c）青少年对自主性的发展特定驱动力，以及（d） 父母编程根据我们团队在青少年干预方面的既定记录， 发展，我们的目标是利用这一竞争延续的机会，最大限度地提高我们的形成 翻译（大脑+行为）发展神经科学数据和理论，为小说的创作提供信息 青少年成瘾的行为治疗（JUNO：对神经发育的快速理解 机会）。本次竞聘延续直接响应NOT-AA-19-010的2019年通知 利息： 特殊 “酒精使用障碍行为治疗的发展和传播”在这里，我们建议 将本项目前4年的定量神经发育数据与 青少年焦点小组（目标1）， 为 饮用 神经发育反应行为治疗 青年（朱诺）。然后，我们将评估这种新的行为治疗对青少年问题的初步影响 并提出了神经发育机制（目标2）。

Project Summary While the field of translational research is gaining increased attention, few teams have successfully integrated brain+behavioral approaches to examine the developing adolescent brain in the context of addiction treatment. PI Feldstein Ewing has been at the forefront of this work, highlighting that in contrast to adults who show reduced reward response in mesocorticolimbic regions during addiction treatment, adolescents' addiction behavior change revolves around enhanced default mode network response [DMN; precuneus, posterior cingulate gyrus (PCC), and middle frontal gyrus (MFG)]. Our foundational studies underscore in this age group, greater DMN response during critical elements of treatment (client language; therapist language) corresponds with greater behavior change (less problem drinking). Our foundational studies have also critically advanced neurodevelopmental addiction theory, illuminating 4 neuro-biobehavioral drivers of adolescent addiction treatment response, including innovative behavioral treatment approaches that planfully integrate a neurodevelopmental perspective and engage: (a) prosocial (vs. problem-based) approaches, (b) adolescents' drastically developing cognitive skills, (c) adolescents' developmentally-specific drive for autonomy, and (d) parents into programming. Following our team's established track record in adolescent intervention development, we aim to use the opportunity of this competitive continuation to maximize our formative translational (brain+behavioral) developmental neuroscience data and theory to inform the creation of a novel behavioral treatment for adolescent addiction (JUNO: Jumpstart Understanding of Neurodevelopmental Opportunity). This competitive continuation directly responds to NOT-AA-19-010's 2019 Notice Interest: of Special "development and dissemination of behavioral treatments for alcohol use disorder.” Here,we propose to merge quantitative neurodevelopmental data from the 1st 4 years of this project with qualitative data from adolescent focus groups (Aim 1), to create a tailored for drinking neurodevelopmentally-responsive behavioral treatment youth (JUNO). We will then evaluate initial impact of this novel behavioral treatment on adolescent problem and proposed neurodevelopmental mechanisms (Aim 2).