3.0T Whole-Body Cardiovascular MRI System

描述（由申请人提供）：本提案的广泛、长期目标是改善患有神经系统、心血管系统或身体系统各种疾病的患者的检测和治疗。美国西北大学范伯格医学院的研究人员建议购买一套3.0T全身磁共振成像系统，用于各种疾病的无创检测。本提案中研究的疾病代表了主要的公共卫生问题，所要求的3.0T扫描仪将为目标疾病涉及的器官提供高分辨率成像。该成像将有助于量化冠状动脉疾病、外周动脉疾病、颈动脉疾病、肺动脉疾病和神经系统疾病的疾病进展。新的3.0T MRI系统的可用性将支持目前NIH资助的项目，以了解这些疾病的机制。与该机构现有的1.5 MRI相比，所要求的新系统将提供改善的信噪比，从而缩短扫描时间并提高空间分辨率。此外，新的3.0T系统比现有的3.0T系统具有更宽的孔径和更短的磁体长度，这将有助于为通常无法获得MR成像的患者打开高质量诊断成像的大门，特别是那些患有幽闭恐怖症，疼痛或不适的患者。利用RF线圈集成技术，多达102个同时连接的线圈元件可以无缝集成到一个检查中，从而实现3D高速、高分辨率并行成像。所要求的仪器的主要用户将包括专门研究神经系统疾病、心血管疾病和胰岛细胞移植的高度成就的科学家。我们的机构拥有丰富的技术经验。一个全面的技术，科学，行政和财务计划，提出了管理使用该仪器在我们的机构。这一申请得到了机构领导的大力支持。在所要求的设备上进行的研究与公共卫生的相关性是为神经系统、身体和心血管疾病开发更准确的诊断工具。长期目标是改善患者治疗并评估潜在的治疗方法。 公共卫生相关性：在所要求的设备上进行的研究与公共卫生的相关性是为神经系统、身体和心血管疾病开发更准确的诊断工具。长期目标是改善患者治疗并评估潜在的治疗方法。将创建两个新职位，以操作和维护所要求的3.0T成像系统。该仪器没有直接和明显的环境影响。

DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve he detection and treatment for patients suffering from various diseases in the neurological, cardiovascular, or body systems. Investigators at the Northwestern University Feinberg School of Medicine propose to purchase a 3.0T whole-body magnetic resonance imaging system for noninvasive detection of various diseases. The diseases to be studied in this proposal represent major public health problems and the requested 3.0T scanner will provide high resolution imaging of organs involved in target diseases. This imaging will help quantify disease progression in coronary artery disease, peripheral artery disease, carotid artery disease, pulmonary artery disease, and neurological disease. The availability of a new 3.0T MRI system will support current NIH-funded projects to understand the mechanisms of these diseases. The requested new system will provide improved signal to noise ratio, resulting in shorter scan times and improved spatial resolution, compared to 1.5 MRI already present at this institution. In addition, the new 3.0T system has wider bore and shorter length of the magnet than current 3.0T systems, which will help open the doors to high-quality diagnostic imaging for patients who typically have not had access to MR imaging, particularly those who are claustrophobic, in pain or discomfort. With RF coil integration technology, up to 102 simultaneously connected coil elements can be seamlessly integrated onto one examination, allowing 3D high-speed, high-resolution parallel imaging. Major users of the requested instrument will include highly accomplished scientists who specialize in neurological diseases, cardiovascular disease, and islet cell transplantation. Extensive technical experience exists in our institution. A comprehensive technical, scientific, administrative, and financial plan is proposed to govern usage of this instrument at our institution. This application had strong support from the institutional leadership. The relevance to public health of research performed on this requested equipment is to develop more accurate diagnostic tools for neurological, body, and cardiovascular diseases. The long-term goal is to improve patient treatments and evaluate potential therapies. PUBLIC HEALTH RELEVANCE: The relevance to public health of research performed on this requested equipment is to develop more accurate diagnostic tools for neurological, body, and cardiovascular diseases. The long-term goal is to improve patient treatments and evaluate potential therapies. Two new positions will be created to operate and maintain the requested 3.0T imaging system. There is no direct and apparent environmental impact of the instrument.