Upgrade of the NMRFAM 750 MHz NMR Spectrometer

描述（由申请人提供）：本提案是针对恢复法案有限竞争，高端仪器赠款计划（S10）计划公告（PA）编号：PAR-09-118。要求提供资金，以更新威斯康星大学麦迪逊分校麦迪逊国家磁共振设施内的布鲁克750兆赫核磁共振分光计。只需花费原系统成本的一小部分，就可以将老化光谱仪恢复到当前的规格，并使其与用户要求的当前脉冲程序和自动化兼容。这一请求将支持重建容纳超导螺线管的低温恒温器（更新的O形环和密封件），用于泵送系统的新控制器，可使系统保持在现场（更换出现故障且供应商不再支持的单元），新的控制台将提供改进的灵敏度，更灵活的脉冲编程，双接收器，改进的可变温度操作，以及重建用于支撑低温探针的低温平台的压缩机。这种NMR光谱仪被威斯康星大学麦迪逊分校和其他机构的NIH资助的研究小组大量使用。在NMRFAM的布鲁克光谱仪中，750 MHz具有最高的场，是使用最频繁的NMR光谱仪。受到对这个品牌比较放心的用户的青睐。用户群有NIH资助的研究项目，涉及各种生物医学领域。 公共卫生相关性：要求提供资金，以更新麦迪逊国家磁共振设施的一台关键核磁共振分光计（Bruker 750 MHz），以纠正其可靠操作方面的严重问题，并使其在灵敏度、脉冲编程灵活性和自动化方面达到目前的标准。仪器的现代化将满足校园内外用户对NMR数据收集能力的需求，这些数据收集能力是进行NIH资助的生物医学研究项目所需的。

DESCRIPTION (provided by applicant): This proposal is directed to the Recovery Act Limited Competition, High-End Instrumentation Grant Program (S10) Program Announcement (PA) Number: PAR-09-118. Funds are requested to upgrade the Bruker 750 MHz NMR spectrometer located in the National Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison. For a fraction of the cost of the original system, this aging spectrometer can be brought back to current specifications and made to be compatible with the current pulse programs and automation demanded by users. This request will support the rebuilding of the cryostat that houses the superconducting solenoid (renewed O-rings and seals), a new controller for the pumping system that keeps the system at field (to replace a unit that is failing and is no longer supported by the vendor), a new console that will provide improved sensitivity, more flexible pulse programming, dual receivers, improved variable temperature operation, and rebuilding of the compressor for the cryoplatform that supports the cryogenic probe. This NMR spectrometer is heavily used by NIH-funded research groups at the University of Wisconsin-Madison and other institutions. Of the Bruker spectrometers at NMRFAM, the 750 MHz has the highest field and is the most heavily used NMR spectrometer. It is favored by users who are more comfortable with this brand. The user base has NIH funded research projects a variety of areas of biomedical interest. PUBLIC HEALTHE RELEVANCE: Funds are requested to upgrade a key NMR spectrometer (Bruker 750 MHz) in the National Magnetic Resonance Facility at Madison to correct serious problems with its reliable operation and to bring it up to current standards of sensitivity, pulse programming flexibility, and automation. Modernization of the instrument will fulfill the demands from users on and off campus for the NMR data collection capability needed to carry out their NIH-funded biomedical research projects.