Promotion of Plasmodium Research and Training in India

描述(由申请人提供)：该项目的目的是提供关于疟原虫属几种疟疾寄生虫的研究培训，以便在印度德里国家疟疾研究所(NIMR)的一个实验室建立可持续的研究能力。两种疟疾寄生虫，特别是恶性疟原虫和间日疟原虫，在印度次大陆造成显著的发病率和一些死亡率。因此，疟原虫生物学提供了一个理想的研究重点，既能加强对这种传染病的预防、治疗和控制，又能为发展中国家机构建设可持续的传染病研究能力提供一个中心。这家美国机构的成员是纽约大学医学院医学寄生虫学系，他们与德里的NIMR有着长期的研究合作历史，可以提供合作研究培训计划所需的补充技能和专业知识。这项提议的核心是由一群在疟原虫生物学各个领域拥有专业知识的美国和印度导师和教职员工在NIMR对五名实习生(三名博士后、一名博士后和一名非学位实习生)进行教育和指导。培训的主题将包括：种群多样性和遗传学、分子进化、遗传关联研究、体外培养、生物信息学、基因组学、蚊子传播研究，以及辅助技能，如科学陈述、拨款申请、科学文献的使用，以及负责任的研究工作培训。这一研究项目将促进对印度一个主要公共卫生问题--疟疾寄生虫--的研究。通过鼓励预防、治疗和控制这种病媒传播的病原体的研究，我们希望在发展中国家的一个机构产生一个建设可持续传染病能力的焦点。

DESCRIPTION (provided by applicant): The aim of this project is to provide research training regarding several species of malaria parasite of the genus Plasmodium, in order to build sustainable research capacity at a laboratory within the National Institute of Malaria Research (NIMR) in Delhi, India. Two species of malaria parasite in particular, P. falciparum and P. vivax, cause significant morbidity and some mortality in the Indian sub-continent. Thus Plasmodium biology provides an ideal focus for research that will both enhance prevention, treatment and control of this infectious disease, as well as providing a focal point for building sustainable infectious disease research capacity at an institution within a developing country. Members of the U.S. institution, the Department of Medical Parasitology at New York University School of Medicine, have a long history of research collaboration with the NIMR in Delhi, and can provide the complementary skills and expertise necessary for a collaborative research training program. At the core of this proposal is the education and instruction of five trainees (three pre-doctoral students, one post-doctoral fellow and one non-degree attaining trainee) at NIMR by a group of U.S and Indian mentors and faculty with expertise in various areas of Plasmodium biology. The topics of training will include: population diversity and genetics, molecular evolution, genetic association studies, in vitro culture, bioinformatics, genomics, mosquito transmission studies, and adjunct skills such as scientific presentation, grant writing, use of the scientific literature, and training in the responsible conduct of research. This research project will promote research into a major public health problem in India, the malaria parasite Plasmodium. By encouraging research in the prevention, treatment and control of this vector-borne pathogen, we hope to generate a focal point for building sustainable infectious disease capacity at an institution in a developing country.