THE NATURAL HISTORY OF PEANUT AND NUT PROTEIN ALLERGY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 花生和坚果是儿童和成人中最敏感的食物，对这些食物的过敏反应可能会很严重，有时甚至是致命的。花生和坚果过敏，与牛奶、鸡蛋、大豆和小麦过敏不同，很少能戒掉；然而，最近的一项研究发现，长大后不再对花生过敏的儿童比例比以前认识到的要高得多。虽然纵向研究表明，在生命早期发现的牛奶、鸡蛋和大豆过敏通常会得到缓解，但只有一份发表的关于花生过敏的报告表明，这种过敏症可以“痊愈”。 这项研究的目的是验证我们的假设，即10-20%的早发性花生或坚果过敏儿童在以后的生活中会变得耐受，并证实我们之前的观察结果，即CAP-RAST FEI(Pharmacia&Upjohn Diagnostics)对抗原特异性IgE抗体的定量是一个很好的临床反应性预测指标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Peanuts and tree nuts are the most allergenic foods in children and adults, and allergic reactions to these foods can be severe and sometimes fatal. Peanut and nut allergy, unlike allergy to milk, egg, soy and wheat, are rarely outgrown; however, a recent study found a significantly higher percentage of children outgrew their peanut allergy than previously appreciated. While longitudinal studies have shown that milk, egg and soy allergies detected early in life often resolve, only one published report on peanut allergy suggests that this allergy can be "outgrown". The purpose of this study is to test our hypothesis that 10-20% of children with early onset peanut or tree nut allergy become tolerant later in life, and confirm our previous observations that quantitation of antigen-specific IgE antibodies by CAP-RAST FEI (Pharmacia & Upjohn Diagnostics) is a good predictor of clinical reactivity.