Translational Research in Biomaterials

摘要 本申请提出了波士顿大学NIH培训计划的第二次更新， 生物材料研究（TRB）。TRB的使命是将博士生培养成跨学科的 和转化研究科学家和工程师。通过他们的TRB培训，学生获得 材料，表面科学，生物材料组织反应的基本和定量的理解， 分子和细胞生物学，以及跨学科课程的培训经验，促进 在学生的“舒适区”之外进行讨论和科学探究。新的更新是：一个初级 教师指导计划，综合学生治理，更好的数据收集，以及更有针对性的努力， 征聘任职人数不足的少数族裔。此外，我们扩大教育，研究和培训 TRB研究员的机会，包括BU的NSF ERC在细胞超材料和合作伙伴关系， 马萨诸塞州总医院和贝斯以色列女执事医疗中心。 TRB计划的基石是课程和联合收割机结合的计划元素 跨学科研究，定量科学，工程学和临床试验的专业课程 和商业，与学生组织的研讨会俱乐部，晚餐与临床医生，培训职业道德， 个人职业规划和专业发展讲习班。我们的目标是教授独特的技能， 在多学科协作团队中茁壮成长所必需的能力，努力满足共同的 在研究、开发、翻译和最终商业化方面的目标。自2009年以来，BU TRB已 有35名跨学科学员（15名女性，20名男性; 26%少数民族; 97%保留; 100%就业; 5.1 年平均博士学位完成; 14名毕业生和20名在校生，其中一人将于下月毕业） 他们在多个方面表现出色，包括发表论文（99），申请专利（7），口头（47）和海报 (155)在地方和国家会议上发言，并参加社会/社群活动（例如， BU研究生工程师学生会主席，高中生辅导等）。所有 学员在TRB资助结束后，通过独立撰写的奖学金（一个 NIH NRSA F31，一个NIH NRSA F30，七个NSF GRFP奖，一个美国药典全球奖学金 奖，一个CIMIT工程奖学金，一个冰川NSF GK 12奖学金，一个Bunano十字架- 学科奖学金，一个克莱尔布斯吕斯奖学金，一个福特基金会奖学金）或NIH R21 /R 01导师赠款。 在这次更新中，TRB的继续，每年通过NIH资助8名学员，与 参与教师的专业知识，有资格和有兴趣的大型和强大的申请人池的可用性 在TRB计划，和校外资金基地，以提供适当的研究环境， 在TRB的支持下，继续支持NIH受训人员超过头两年。

ABSTRACT This application proposes the second renewal of Boston University's NIH training program, Translational Research in Biomaterials (TRB). The mission of the TRB is to develop PhD students into interdisciplinary and translational research scientists and engineers. Through their TRB training, students acquire a fundamental and quantitative understanding of materials, surface science, biomaterial-tissue response, and molecular and cell biology, as well as training experiences in interdisciplinary programs that promote discussion and scientific inquiry in areas outside students’ “comfort zones.” New for this renewal are: a junior faculty mentoring plan, integrated student governance, better data collection, and more targeted efforts for underrepresented minority recruitment. Furthermore, we expand the educational, research, and training opportunities for TRB Fellows to include BU’s NSF ERC in Cellular Metamaterials and partnerships with Massachusetts General Hospital and Beth Israel Deaconess Medical Center. The cornerstones of the TRB program are the curriculum and the program elements that combine interdisciplinary research, quantitative science, engineering, and translational-based courses in clinical trials and business, with student-organized seminar club, dinners with clinicians, training in professional ethics, individual career plans, and professional development workshops. Our aim is to teach the unique skills and competencies that are essential to thrive in a multidisciplinary collaborative team striving to meet common goals in research, development, translation, and, ultimately, commercialization. Since 2009, the BU TRB has had 35 interdisciplinary trainees (15 women, 20 men; 26% minority; 97% retention; 100% employment; 5.1 years average PhD completion; 14 graduates and 20 current students, one of whom will graduate next month) who have excelled on multiple fronts, including publishing papers (99), filing patents (7), oral (47) and poster (155) presentations at local and national meetings, and participating in societal / community activities (e.g., President of the BU Student Association of Graduate Engineers, tutoring for high school students, etc.). All trainees have been supported after their TRB funding ended through independently written fellowships (one NIH NRSA F31, one NIH NRSA F30, seven NSF GRFP awards, one US Pharmacopeial Global Fellowship Award, one CIMIT Engineering Fellowship, one Glacier NSF GK12 Fellowship, one BUnano Cross- Disciplinary Fellowship, one Clare Booth Luce Fellowship, and one Ford Foundation Fellowship) or the NIH R21 / R01 grants of their mentors. In this renewal, the continuation of the TRB, with eight trainees per year funded via NIH, is aligned with the expertise of participating faculty, the availability of a large and strong applicant pool eligible for and interested in the TRB program, and an extramural funding base to provide the appropriate research environment and continued support for NIH trainees beyond their first two years supported by the TRB.