Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)

项目摘要/摘要 加勒比、中美洲和南美洲艾滋病毒流行病学网络是一个既定的 国际流行病学数据库内富有成效的网络，以评估艾滋病(LeDEA)方案。 CCASAnet是在2006年第一个leDEA供资周期期间创建的，它汇集了临床、统计学、 来自阿根廷、巴西、智利、阿根廷、巴西和智利的艾滋病毒临床护理和研究站点的流行病学和信息学资源 海地、洪都拉斯、墨西哥和秘鲁，以及美国纳什维尔的协调中心。在一起，成员们 对该区域和整个艾滋病毒研究领域出现的科学机会作出回应 遍布全球的网络。范德比尔特大学医学中心(VDCC)CCASAnet数据协调中心 管理CCASAnet财团，并努力协调和分析由 参与站点。VDCC还提供指导和教育，以加强临床研究和数据 CCASAnet站点的管理能力，提拔初级研究人员，并催化持续增长 在该地区的科学领导地位。在接下来的五年里，CCASAnet将评估艾滋病毒连续体中的不平等现象 护理的重要性；新冠肺炎大流行对艾滋病毒护理提供的影响；弱势人群的结果 包括移民、“后续行动失败者”和孕妇；决定因素和预防非 传染病；以及携带和不携带艾滋病毒的结核病患者的治疗结果。我们还将描述 青少年、变性人和非传染性疾病的心理社会、行为和非传染性疾病的临床结果 老年人通过新的前瞻性队列嵌套在CCASAnet回溯性临床队列。我们会 继续开发和应用创新的生物统计学和信息学方法，提高我们的生产力 与IeDEA其他区域合作，并在现场评估、数据协调和 数据共享计划。通过这些活动，CCASAnet 4将有助于推动艾滋病毒科学 流行病学和支撑国际研究合作的信息科学。

PROJECT SUMMARY/ABSTRACT The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network within the International epidemiology Databases to Evaluate AIDS (leDEA) program. CCASAnet was created in 2006 during the first leDEA funding cycle and has brought together clinical, statistical, epidemiologic, and informatics resources from HIV clinical care and research sites in Argentina, Brazil, Chile, Haiti, Honduras, Mexico, and Peru, along with a coordinating center in Nashville, USA. Together, the members of the CCASAnet collaboration respond to scientific opportunities arising in the region and across HIV research networks worldwide. The CCASAnet Data Coordinating Center at Vanderbilt University Medical Center (VDCC) manages the CCASAnet consortium and works to harmonize and analyze the complex databases generated by participating sites. The VDCC also provides mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region. Over the next five years, CCASAnet will assess inequities in the HIV continuum of care; the impact of the COVID-19 pandemic on HIV care delivery; outcomes in vulnerable populations including migrants, those "lost to follow-up," and pregnant women; determinants and prevention of non- communicable diseases; and treatment outcomes in TB patients with and without HIV. We will also characterize psychosocial, behavioral, and non-communicable disease clinical outcomes in adolescents, transgender, and older persons through new prospective cohorts nested in the CCASAnet retrospective clinical cohort. We will continue to develop and apply innovative biostatistics and informatics methods, grow our productive collaborations with other IeDEA regions, and provide leadership in the site assessment, data harmonization, and data sharing initiatives. Through these activities, CCASAnet 4 will help advance both the science of HIV epidemiology and the information science that underpins international research collaboration.