Tennessee Valley Cooperative Human Tissue Network

项目摘要 自1987年以来，合作人体组织网络（CHTN）作为一个来源发挥了重要作用。 用于生物医学研究的人体组织为此，西部分区的首要目标是 范德比尔特大学医学中心（CHTN-VUMC）的CHTN将继续为科学服务， 社区通过采购和分发成人生物标本，利用严格的质量管理 该计划旨在维持高效和多产的生物储存库运行。这一目标的主要方面 是具有临床应用前景的高质量实体组织和生物液体的定制集合。 注释和严格的质量管理体系的应用程序的各个方面。 将通过发射另外两个收集数据的卫星站点来扩大人口覆盖面。新 服务，如单细胞悬液，肿瘤浸润淋巴细胞的分离和TMA构建 提出了响应不断变化的研究者需求的需求。此外，肿瘤前和罕见 病变将被储存以促进肿瘤进展的研究。CHTN-VUMC将坚持 严格的伦理标准，以保护人类受试者和患者机密，并将合作伙伴 与VUMC倡导计划，以吸引患者，并提供参与的机会， research.我们还建议作为信息学（IT）跨网络协调中心 负责第二版的“调查员IT”系统，利用网络服务和强大的 现代化的技术先进的平台，并确保遵守IT安全的最佳做法。在其 事业部IT战略，CHTN-VUMC将开发和整合新的业务模式和新的 提高运营效率的信息学策略，包括与VUMC BioVu合作 将组织样本与大型临床数据集联系起来的项目。营销工作将包括以下举措： 提高科学界对CHTN的认识，包括加强使用社交媒体， CHTN-VUMC将通过以下方面的领导，积极为生物储存科学和教育做出贡献： 国际生物与环境知识库学会（International Society for Biological and Environmental Repositories）。 CHTN-VUMC在网络IT开发方面的领导地位使该部门成为唯一有资格担任 中央网站。稳健的样本分发记录，将64，358份样本运送至 在过去的6.5年中，1011名研究人员，突出了现有CHTN-VUMC的能力 基础设施演进CHTN-VUMC在下一个资助期的目标包括在这些基础上建立 提高网络、调查人员和科学家的效率和沟通 社区

PROJECT SUMMARY The Cooperative Human Tissue Network (CHTN) has played an important role since 1987 as a source for human tissues for biomedical research. To this end, the overarching goal of the Western Division of the CHTN at Vanderbilt University Medical Center (CHTN-VUMC) is to continue to serve the scientific community by procuring and distributing adult biospecimens, utilizing a stringent quality management program to maintain a highly efficient and productive biorepository operation. Key aspects of this goal are the prospective customized collection of high quality solid tissues and biofluids with clinical annotation and application of a rigorous Quality Management System to all aspects of the program. Demographic coverage will be expanded by launching two additional satellite sites for collection. New services, such as single-cell suspensions, isolation of tumor infiltrating lymphocytes and TMA Build On Demand in response to changing investigator needs are proposed. In addition preneoplastic and rare lesions will be banked to facilitate research in tumor progression. The CHTN-VUMC will adhere to rigorous ethical standards for protection of human subjects and patient confidentiality, and will partner with the VUMC advocacy program to engage patients and provide opportunities for participation in research. We also propose to serve as the Informatics (IT) trans-network Coordinating Center responsible for the second version of the “Investigators IT” system, utilizing web services and a strong modern technologically advanced platform and ensuring adherence to IT security best practices. In its divisional IT strategy, CHTN-VUMC will develop and integrate new business models and novel informatics strategies to improve operational efficiency, including partnering with the VUMC BioVu project to link tissue samples to large clinical datasets. Marketing efforts will include initiatives to increase awareness of CHTN in the scientific community, including enhanced use of social media, and CHTN-VUMC will actively contribute to biorepository science and education through leadership in societies such as the International Society for Biological and Environmental Repositories. CHTN-VUMC's leadership in network IT development makes the division uniquely qualified to serve as the central IT site. A robust track record of specimen distribution, with 64,358 specimens shipped to 1011 investigators over the past 6.5 years, highlights the capabilities of the existing CHTN-VUMC infrastructure. CHTN-VUMC goals in the next funding period include building upon these foundational achievements to improve efficiency and communication within the network, investigators and scientific community.