Instrumentation to Support the Research and Resources of the Viper Resource Center at Texas A&M University-Kingsville

标题：支持毒蛇资源中心研究和资源的仪器 德克萨斯农工大学金斯维尔分校 项目总结： 天然产品一直是药物设计的主要基础，蛇以及其他 动物毒液具有巨大的未开发潜力。蛇毒及其抗蛇毒研究领域 完全依赖于获得可靠和可再生的毒液相关资源 由国家天然毒素研究中心(NNTRC)开发。蛇毒有 提供了分子探针，已经被用来破译无数复杂的生理 和病理生理过程，并已成为发展的起点 几种重要的药物。NNTRC需要关键的设备来推进 研究水平，以及继续为其提供高质量的研究资源 顾客。所需的设备和仪器，Optima Max-XP台式机 超速离心机、Nanosight NS300纳米粒子跟踪分析系统(NTA)和One 在提案中，LabConco®冻干机非常适合支持和进行研究 NNTRC更上一层楼。家长拨款的具体目标是：1)运营国家 天然毒素研究中心作为资源中心，提供高质量的毒液和 支持国家和国际项目的生物和生物医学研究的产品； 2)发展和扩大蛇的收藏、专门服务和外联方案，以 支持毒液相关研究在美国的增长；以及3)进行最先进的应用 研究计划，以支持与毒液相关的新研究服务的开发。访问 这些设备和仪器将使NNTRC能够实现其特定目标并允许 研究人员将在寻找毒液衍生疗法方面取得重要进展。 相关性： NNTRC的资源已被应用于广泛学科的研究 从毒液进化的基因组和蛋白质组研究到翻译研究 伤害性和抗蛇毒疗法，这项研究得到了多家NIH的支持 I/C、NSF、国防部以及国家和国际研究机构。除了……之外 它作为国家毒蛇和毒液资源的角色，这些仪器将为本科生提供， 来自代表性不足地区的毕业生和教职员工有机会参加 最先进的研究和进一步了解毒素的机制及其在 蛇毒的病理生理学，以设计下一代疗法。

Title: Instrumentation to Support the Research and Resources of the Viper Resource Center at Texas A&M University-Kingsville PROJECT SUMMARY: Natural products have been a main foundation of drug design and snakes as well as other animal venoms have a vast unexploited potential. The fields of venom and anti-venom research are absolutely dependent on access to the reliable and reproducible venom-related resources developed by the National Natural Toxin Research Center (NNTRC). Snake venoms have provided molecular probes that have been used to decipher numerous complex physiological and pathophysiological processes and have served as the starting point for the development of several important classes of drugs. The NNTRC is in need of equipment crucial for advancing the level of research as well as continuing to provide high-quality research resources to its customers. The equipment and instrumentation being requested, Optima MAX-XP Tabletop Ultracentrifuge, a NANOSIGHT NS300 Nanoparticle Tracking Analysis (NTA), and one LabConco® lyophilizers, in the proposal are ideally suited to support and take research at the NNTRC to the next level. The specific aims for the parent grant are to: 1) operate the National Natural Toxins Research Center as a resource center that provides high quality venom and products that support biological and biomedical research to national and international programs; 2) develop and expand the collection of snakes, specialized services and outreach programs to support growth of venom related research in the U.S.; and 3) conduct a state-of-the-art applied research program to support the development of new venom-related research services. Access to these equipment and instruments will enable the NNTRC to fulfill its specific aims and allow researchers to make important advances in the search for venom-derived therapeutics. RELEVANCE: The resources of the NNTRC have been applied to research in a wide range of disciplines ranging from genomic and proteomic studies on venom evolution to translational research on nociception and anti-venom therapeutics, research that has been supported by multiple NIH I/C’s, the NSF, Dept of Defense, and national and international research agencies. In addition to its roles as a national viper and venom resource, the instruments will provide undergraduate, graduate and faculty from underrepresented areas with the opportunity to participate in state-of- the-art research and further understand the mechanisms of toxins and their roles in the pathophysiology of snake envenoming in order to design next generation therapeutics.