Center for Appalachian Research in Environmental Sciences

项目总结--总体 肯塔基大学阿巴拉契亚环境科学研究中心(UK-CARE)将 在我们早期成功的基础上，吸取经验教训，通过双重关注加强我们的使命 更好地了解暴露途径和新出现的环境健康威胁，并优化研究 翻译。我们的使命是专注于暴露途径，以更好地匹配社区关注的问题，并 强调研究性翻译。我们的价值观反映了强大的、多方向的社区-学术合作伙伴关系， 重新致力于尊重和促进有意义的过程、程序和政策 多样性、公平性和包容性。负责任的研究是我们中心的基础， 认识到严谨和可重复的多学科团队科学的基本价值。我们的目标是 (A)推进多学科环境健康科学；(B)分析有机污染物并追踪- (C)培养处于早期阶段的和已建立的调查人员；(D)与社区一起学习，并向社区学习， 帮助提供信息和翻译我们的研究；以及(E)与调查人员和 社区合作伙伴促进研究翻译。我们将推动EHS在翻译领域的发展 阿巴拉契亚农村居民了解到的三个高度整合的科学主题：1)健康影响 水中污染物(水)；2)室内和室外空气污染物(空气)对健康的影响； 3)新出现的环境健康威胁(新威胁)。中心假设是 通过环境暴露途径(如水、空气)和新出现的污染物暴露于已确定的污染物 环境健康威胁，再加上生活方式和社会风险因素，导致 阿巴拉契亚农村地区的慢性病发病率和健康差距高得不成比例。英国-CARE 利用强大和多样化的EHS基础和社区参与的研究来满足以下需求 阿巴拉契亚地区的乡村社区。我们将支持和指导调查人员，以便他们能够接触到 研究中的里程碑：(1)提出基本问题；(2)应用和综合；(3)实施和 调整；(4)将想法付诸实践；(5)创造影响。简而言之，英国CARE将利用其资源 加强英国的EHS，同时降低阿巴拉契亚农村地区的健康风险和差距。一个集成的 健康科学设施核心、环境科学分析化学核心和社区 项目核心是这项工作不可或缺的一部分，因为这些核心将在分析方面提供专门的支持 化学，微量元素分析，生物样品管理，生物信息学和桥梁中心和 社区优先事项。试点项目计划支持发展研究和新的科学方向， 促进对解决具有挑战性的环境健康问题感兴趣的科学家的职业生涯。英国- CARE将通过协作的EHS对阿巴拉契亚农村产生积极影响，旨在产生和 传播新知识和转化研究，为临床决策和政策制定提供信息。

PROJECT SUMMARY – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will build on our early successes, capitalize on lessons learned, and enhance our mission through a dual focus on better understanding exposure pathways and emerging environmental health threats and optimizing research translation. Our Mission is to focus on exposure pathways to better match with community concerns and to emphasize research translation. Our Values reflect strong, multidirectional community-academic partnerships, with a renewed commitment to meaningful processes, procedures, and policies that respect and promote diversity, equity, and inclusivity. Responsible conduct of research is at the foundation of our Center, appreciating the essential value of rigorous and reproducible multidisciplinary team science. Our goals are to (a) advance multidisciplinary environmental health science (EHS); (b) analyze organic contaminants and trace- elements; (c) cultivate early-stage stage and established investigators; (d) learn with and from the community, helping to inform and translate our research; and (e) build science communication skills with investigators and community partners to boost research translation. We will advance EHS across the translational spectrum around three highly integrated science themes informed by residents of rural Appalachia: 1) Health Impacts of Waterborne Contaminants (WATER); 2) Health Impacts of Indoor and Outdoor Airborne Contaminants (AIR); and 3) Emerging Environmental Health Threats (EMERGING THREATS). The central hypothesis is that exposure to established contaminants via environmental exposure pathways (e.g., water, air) and emerging environmental health threats, combined with lifestyle and societal risk factors, contributes to the disproportionately high incidence of chronic diseases and health disparities in rural Appalachia. UK-CARES draws on a strong and diverse base of EHS and community-engaged research to meet the needs of communities in rural Appalachia. We will support and mentor investigators so they can reach the translational milestones in research: (1) asking fundamental questions; (2) applying and synthesizing; (3) implementing and adjusting; (4) moving ideas to practice; and (5) creating impact. In short, UK-CARES will leverage its resources to enhance EHS at UK while also reducing health risks and disparities in rural Appalachia. An Integrated Health Sciences Facility Core, Analytical Chemistry Core for Environmental Sciences, and Community Engagement Core are integral to this effort, as these cores will provide dedicated support in analytical chemistry, trace-elements analysis, biospecimen management, and bioinformatics and bridge Center and community priorities. The Pilot Project Program supports developing research and new scientific directions, advancing the careers of scientists interested in tackling challenging environmental health questions. UK- CARES will positively impact rural Appalachia through collaborative EHS designed to generate and disseminate new knowledge and translate research to inform clinical decision making and policy development.