Integrated Health Sciences Facility Core

摘要-综合健康科学中心 综合健康科学设施核心（IHSFC）促进环境中心的目标， 健康和司法在北方曼哈顿（CEHJNM）通过支持我们的成员，社区合作伙伴， 现有的研究项目，并促进新的跨学科研究，重点是环境健康和 正义对于此次竞争性更新，CEHJNM对其设施核心进行了重组和微调，以更好地服务于 中心成员的需求，提高效率，加强跨学科的研究。我们以前的曝光 评估设施核心合并到IHSFC，现在由Steven Chillrud博士和Regina博士共同指导 桑泰拉此外，由于加里米勒博士抵达哥伦比亚大学，IHSFC现在包括他的 非靶向分析实验室，支持代谢组学和代谢组学研究的非靶向分析。 IHSFC现在汇集了六个已建立的实验室的专业知识：环境暴露评估 实验室，由Chillrud博士领导[拉蒙多尔蒂地球观测站（LDEO）];过敏原和生物气溶胶实验室，由 博士马特Perzanowski [哥伦比亚大学欧文医学中心（CUIMC）];微量有机物实验室，由博士领导。 Beizhan Yan（LDEO）;生物储存和生物分析实验室，由Santella博士领导（CUIMC）;非靶向分析 实验室，由米勒博士（CUIMC）领导;和多元素痕量分析实验室，由凯瑟琳席林博士（CUIMC）领导。 这种整合增强了我们提供全面方法的能力， 分析环境和生物样品，从毒理学和机理研究， 临床、基于人群和基于社区的参与性研究。IHSFC使研究人员能够 他们的研究从假设产生的非目标扫描到详细的，高度精确的分析， 暴露或影响的特定标记。IHSFC与研究设计和数据无缝协作 科学设施核心，为研究设计和功效计算提供宝贵的概念输入， 在研究的第一阶段和实施过程中提供收集和数据库支持。 IHSFC的服务包括就样本收集方法和暴露研究设计、处理和 （环境和生物）样品存档，支持环境正义项目和社区 核心活动，开发和验证新的采样设备，维护和出借 现场设备，以及应对暴露紧急情况和社区需求。此外，除了提供 为CEHJNM成员提供服务，包括为CEHJNM试点项目提供无偿或低成本服务，IHSFC 还为学生，博士后，研究员，初级教师和工作人员提供培训，以促进职业发展， 独立我们相当多的专业知识链接中心成员和初级教师周围的其他资源 LDEO和CUIMC。我们的专业知识使中心的成员能够识别和描述 健康的环境决定因素的影响，最终催化CEHJNM的目标， 通过研究、培训和伙伴关系实现环境健康和公平。

SUMMARY – INTEGRATED HEALTH SCIENCES FACILITY CORE The Integrated Health Sciences Facility Core (IHSFC) promotes the goals of the Center for Environmental Health and Justice in Northern Manhattan (CEHJNM) by supporting our members, community partners, and existing research projects and by fostering new interdisciplinary research focusing on environmental health and justice. For this competitive renewal, the CEHJNM restructured and fine-tuned its Facility Cores to better serve Center members’ needs, increase efficiency, and enhance interdisciplinary research. Our previous Exposure Assessment Facility Core is merged into the IHSFC, now co-directed by Drs. Steven Chillrud and Regina Santella. In addition, as a result of Dr. Gary Miller’s arrival at Columbia University, the IHSFC now includes his Untargeted Analysis Lab, which supports untargeted analysis for metabolomic and exposomic research. The IHSFC now brings together the expertise of six established labs: Environmental Exposure Assessment Lab, led by Dr. Chillrud [Lamont Doherty Earth Observatory (LDEO)]; Allergens and Bioaerosols Lab, led by Dr. Matt Perzanowski [Columbia University Irving Medical Center (CUIMC)]; Trace Organics Lab, led by Dr. Beizhan Yan (LDEO); Biorepository and Bioanalysis Lab, led by Dr. Santella (CUIMC); Untargeted Analysis Lab, led by Dr. Miller (CUIMC); and Multi-element Trace Analysis Lab, led by Dr. Kathrin Schilling (CUIMC). This integration augments our ability to provide comprehensive approaches with an array of state-of-the-art analyses for both environmental and biological samples, ranging from toxicology and mechanistic studies to clinical, population-based, and community-based participatory studies. The IHSFC enables investigators to take their studies from hypothesis-generating untargeted scanning to detailed, highly precise analysis of specific markers of exposures or effects. The IHSFC works seamlessly with the Study Design and Data Science Facility Core that provides invaluable conceptual input in study design and power calculations, data collection, and database support in a study’s first stages and implementation. IHSFC services include consults on sample collection methods and exposure study design, processing and archiving samples (environmental and biological), supporting environmental justice projects and Community Engagement Core activities, developing and validating new sampling equipment, maintenance and loaning of field equipment, and responding to exposure emergencies and community needs. Further, beyond delivering services to CEHJNM members, including pro-bono or low-cost services for CEHJNM pilot projects, the IHSFC also provides training for students, postdocs, fellows, junior faculty, and staff to foster career development and independence. Our considerable expertise links Center members and junior faculty to other resources around LDEO and CUIMC. Our range of expertise empowers Center’s members to identify and characterize the impacts of environmental determinants of health, ultimately catalyzing the CEHJNM’s goal to advance environmental health and equity through research, training, and partnerships.