Einstein Aging Study

摘要 阿尔茨海默病和相关痴呆(ADRD)的病因是多因素的，目前缺乏 在疾病改变疗法中，越来越需要更好地理解可改变风险的作用 各种因素。爱因斯坦老龄化研究项目(EAS P01)更新的首要目标是 阐明将行为、社会/情绪和代谢健康以及环境因素联系起来的途径 到ADRD发病前的认知功能下降。EAS队列是来自布朗克斯的以社区为基础的多样化样本 ，并提供了机会来检查与种族/民族差异有关的社会因素 认知健康。在本资助期间，我们开发并应用了生态瞬时评估。 (EMA)方法，并将它们与强有力的基于临床的认知表现测量相结合，以早期识别 认知改变和认知衰退的可改变的危险因素。我们将通过以下方式扩展这一经验 利用移动设备捕捉风险因素和认知表现的动态时变特性 因为参与者参与了他们日常的活动。我们在门诊评估方面的经验与 我们在传统方法方面的专业知识和强大的统计专业知识是这项建议的主要优势。这个 健壮的传统认知电池提供特定领域的认知状态和衰退测量， 支持轻度认知障碍(MCI)的诊断，并便于与其他研究进行比较。我们 提出四个主题相关的项目，以测量与主要认知相关的暴露 结果：认知表现、认知功能下降、轻度认知障碍和血源性AD 生物标志物。项目1将评估睡眠健康、体力活动和久坐行为的综合影响。 项目2将调查社会/情绪健康、炎症和 生物老化的标记物。项目3将测量特定人暴露在空气污染中的情况，以调查 颗粒物暴露的影响。项目4利用2型糖尿病患者的持续血糖监测来 检查血糖调节的效果。这些综合项目中的资源和专业知识将是 由六个紧密相连的核心支持。这些综合资源将增强我们检查生物的能力。 暴露可能与包括炎症在内的认知结果相关联的机制， 血管突起，神经退化的标志。信息将为未来的有针对性的干预提供信息 预防延迟ADRD发病。EAS研究人员将继续指导初级调查人员培训下一名 一代认知老化的科学家以创新的方法进行临床研究。通过正在进行的 国家和国际合作EAS将继续作为ADRD研究的宝贵资源 社区。

ABSTRACT The etiology of Alzheimer’s disease and related dementias (ADRD) is multifactorial and given the current lack of disease-modifying treatments, there is a growing need to better understand the roles of modifiable risk factors. The overarching goal of this Einstein Aging Study Program Project (EAS P01) renewal is to elucidate pathways linking behavioral, social/emotional and metabolic health, as well as environmental factors to cognitive decline prior to onset of ADRD. The EAS cohort is a diverse community-based sample from Bronx County, NY, and provides the opportunity to examine social factors related to racial/ethnic disparities in cognitive health. In the current funding period, we developed and applied ecological momentary assessment (EMA) methods and aligned them with robust clinic-based measures of cognitive performance to identify early cognitive changes and modifiable risk factors for cognitive decline. We will expand upon this experience by utilizing mobile devices that capture the dynamic time-varying nature of risk factors and cognitive performance as participants engage in their usual daily activities. Our experience with ambulatory assessment paired with our expertise in conventional methods and strong statistical expertise are major strengths of the proposal. The robust conventional cognitive battery provides domain specific measures of cognitive status and decline, supports the diagnosis of mild cognitive impairment (MCI) and facilitates comparison with other studies. We propose four thematically connected projects, to measure exposures in relation to the primary cognitive outcomes: cognitive performance, cognitive decline, mild cognitive impairment, and blood-based AD biomarkers. Project 1 will assess combined effects of sleep health, physical activity and sedentary behavior. Project 2 will investigate the independent, and joint effects of social/emotional health, inflammation and markers of biological aging. Project 3 will measure person-specific exposure to air pollution to investigate the effects of particulate matter exposure. Project 4 utilize continuous glucose monitoring in Type 2 diabetics to examine effects of glucose regulation. The resources and expertise within these integrated projects, will be supported by six closely linked cores. These combined resources will enhance our ability to examine biological mechanisms that may underlie associations of exposures with cognitive outcomes including inflammation, vascular processes, markers of neurodegeneration. Information will inform future targeted interventions to prevent of delay ADRD onset. EAS researchers will continue to mentor junior investigators to train the next generation of cognitive aging scientists in innovative approaches to clinical research. Through oongoing national and international collaborations the EAS will continue as a valuable resource for the ADRD research community.