Single viewpoint panoramic imaging technology for colonoscopy

摘要 结肠癌是美国和全世界癌症死亡的主要原因。结肠镜检查是 首选的筛选方法，在美国估计每年花费约240亿美元。不幸的是很多 由于病变可能隐藏在结肠的褶皱和弯曲之后而无法观察到，因此会错过病变。电流 增加视场的方法是无效的，并且一些非常昂贵，从而阻止了 将这些方法应用于临床实践。 在这个建议中，我们建议开发一种单视点全景成像技术， 360-结肠的角度侧视图所提出的全景成像系统包括成像阵列， 系统共享相同的观点，解决了重建全景图像的关键障碍， 多个成像系统。我们将开发一种独特的单片光学机械设计， 子系统精确地没有主动对准。所提出的单视点全景成像系统可以 或者集成到新的结肠镜中，使得结肠镜将具有标准的前视图和360度的前视图， 度全景侧视图，或作为当前商业结肠镜的卡扣式附件构建， 提供360度全景侧视。 为了证明所提出的单视点全景系统的成像能力，我们将首先开发 并表征标准结肠镜的单视点全景附件，然后评估 检测息肉的性能，并与标准结肠镜进行比较。 所提出的单视点全景成像系统将最大限度地检测息肉， 降低结肠癌的发病率。它将使患者和社会受益五倍：降低 结肠癌，减少“间隔期”癌症的机会，降低总体发病率和死亡率，增加 结肠镜检查之间的间隔，并减少这种疾病的经济负担。

Abstract Colon cancer is a leading cause of cancer death in the United States and worldwide. Colonoscopy is the preferred screening method at an estimated annual cost of about $24 billion in the US. Unfortunately, many lesions are missed because they can remain hidden from view behind folds and flexures of the colon. Current methods of increasing the field of view are ineffective and some are very expensive, preventing the adoption of these methods into clinical practice. In this proposal, we propose to develop a single viewpoint panoramic imaging technology which can provide 360-degree side-view of the colon. The proposed panoramic imaging system consists of an array of imaging systems which share the same viewpoint, addressing the key barrier in reconstructing the panoramic image from multiple imaging systems. We will develop a unique monolithic opto-mechanical design to integrate all subsystems precisely without active alignment. The proposed single viewpoint panoramic imaging system can be either integrated to the new colonoscope so that the colonoscope will have standard forward view and 360- degree panoramic side-view, or built as a snap-on attachment for the current commercial colonoscopes to provide 360-degree panoramic side-view. To demonstrate the imaging capability of the proposed single viewpoint panoramic system, we will first develop and characterize a single viewpoint panoramic attachment for the standard colonoscope, and then evaluate the performance in detecting polyps and compare to a standard colonoscope. The proposed single viewpoint panoramic imaging system will maximize the detection of polyps and substantially reduce the incidence of colon cancer. It will benefit the patients and society in five-fold: reducing incidence of colon cancer, reducing the chance of ‘interval’ cancer, decreasing overall morbidity and mortality, increasing the interval between colonoscopies, and reducing the economic burden of this disease.