Project 1 - Changes in Daily Stress and Well-Being

项目摘要/摘要 MIDUS每日日记项目的目标是确定日常压力的短期波动如何 这些过程会影响整个中年和成年后的长期健康和幸福。具体目标是： (1)评估三种情况下日常压力源和日常幸福感的多方面变化 跨越20年；(2)研究日常应激过程如何扰乱唾液皮质醇的昼夜节律 和α淀粉酶；以及(3)通过添加新的评估来增强来自MIDUS认知项目的数据 日常认知：非建设性的重复思维(侵入性思维)和记忆缺陷。这些目标将 通过对参与调查的参与者进行第三波纵向数据收集 之前的MIDUS I&II日记。纵向样本将由1000个个体组成，这些个体是从 MIDUS随机数字拨号(RDD)参与者和来自密尔沃基非裔美国人的200名参与者 样本。收集方案将继续使用为期8天的电话日记，研究日常压力源和井- 结合多项唾液评估(4次×4天)以确定唾液皮质醇和 该项目的新生物标记物：唾液α淀粉酶(SAA)。MIDUS每日日记项目将继续 将其他MIDUS项目中获得的丰富指标(社会人口学、个性、认知)纳入 我们的分析是为了研究它们如何与日常压力过程中的变化相关。该项目还将使用 从生物标记物、基因表达和神经科学项目中获得的信息，以检查如何变化 在日常应激过程中预测各种健康指标的变化(例如，稳态负荷、炎症 过程、神经内分泌调节、心血管风险)。

Project Summary/Abstract The objective of the MIDUS Daily Diary Project is to determine how short term fluctuations in daily stress processes impact longer-term health and well-being throughout midlife and later adulthood. Specific aims are: (1) To assess changes in multiple aspects of daily stressors and daily well-being across three occasions spanning 20 years; (2) To investigate how daily stress processes disrupt diurnal rhythms of salivary cortisol and alpha amylase; and (3) To enhance data from the MIDUS cognitive project by adding new assessments of everyday cognition: unconstructive repetitive thinking (intrusive thoughts) and memory failures. These aims will be addressed by conducting the third wave of longitudinal data collection from participants who participated in the previous MIDUS I & II Diary. The longitudinal sample will consist of 1000 individuals selected from the MIDUS random digit dialed (RDD) participants and 200 participants from the African-American Milwaukee sample. The collection protocol will continue to use an 8-day telephone diary study of daily stressors and well- being combined with multiple assessments of saliva (4 occasions × 4 days) to ascertain salivary cortisol and a new biomarker for this project: salivary alpha amylase (sAA). The MIDUS Daily Diary Project will continue to incorporate the rich measures (sociodemographic, personality, cognitive) obtained in other MIDUS projects in our analyses to study how they relate to changes in daily stress processes. This project will also use information obtained from the biomarker, gene expression and neuroscience projects to examine how changes in daily stress processes predict changes in various indicators of health (e.g., allostatic load, inflammatory processes, neuroendocrine regulation, cardiovascular risk).