Developmental Neuroscience and Child Psychopathology

发展神经科学和精神病理学有很大的潜力来帮助我们理解 精神疾病的致病途径和机制。专注于这一领域的T32由以下人员共同领导 Luby博士和Bch博士(在发展精神病理学和神经科学方面具有免费的专业知识)，以及 在前两个融资周期中非常成功，享有竞争激烈的国家申请者池 并成功地将完成该计划的青年科学家投入到研究事业和外部 资金问题。我们寻求更新这项培训拨款，在更广泛的神经成像领域增加新的专业知识 MEASURES，以及新的教师导师，他们在遗传学、肠道微生物群和 睡眠/昼夜节律对神经发育和精神病理风险的影响。从公共卫生的角度来看， 在发育神经科学和精神病理学领域注入新的研究科学家 仍然是一个高度优先的问题。拟议的多学科培训方法是由一个概念性的 一种模型，该模型认识到精神障碍的风险、发病和过程是通过复杂的 大脑发育过程受环境、心理社会、认知、情感、 遗传和生物因素从子宫开始相互作用，并持续整个发育过程。 圣路易斯华盛顿大学(WUSTL)的许多研究人员都有丰富的经验记录 在儿童神经成像和相关方法的许多方面，包括对结构和功能的关注 儿童早期(包括新生儿)功能性近红外磁共振检查 光谱学(FNIR)、诱发反应电位(ERP)和高密度漫反射光学断层扫描(HD- 点)。此外，WUSTL在精神遗传学、肠道微生物组工作和 睡眠/昼夜节律，许多研究人员可以利用他们的专业知识来理解 发展精神病理学的神经生物学。项目导师拥有丰富的可用资源 数据库来源于纵向研究，其中几项研究始于儿童早期和子宫内。导师 还提供了一个独特的多学科培训环境，以便从事这一令人兴奋的领域 发展，鉴于WUSTL学校儿童研究人员之间建立的合作 医学临床和基础系，以及神经科学和神经成像计划的状况，请访问 WUSTL一直处于发展、认知和情感神经科学的前沿。互动 基础和临床发育神经科学的研究人员之间提供了一个持续的机会来帮助 培养下一代年轻的科学家，他们可以探索有关发育病因学的问题 精神病理学从人类行为的核心心理和神经机制的角度出发 跨越精神病理学的传统界限，这是NIMH研究领域标准的核心方法 主动性(RDoC)。

Developmental neuroscience and psychopathology have great potential to inform the understanding of the causal pathways and mechanisms of mental illness. This T32, which is focused on this domain, is co-led by Drs. Luby and Barch (with complimentary expertise in developmental psychopathology and neuroscience), and has been very successful in the first two cycles of funding, enjoying a highly competitive national applicant pool and successfully launching the young scientists completing the program into research careers and external funding. We seek to renew this training grant, adding new expertise in a wider range of neuroimaging measures, as well as new faculty mentors with expertise in the effects of genetics, the gut microbiome, and sleep/circadian rhythms on neurodevelopment and risk for psychopathology. From a public health perspective, an infusion of new research scientists in the area of developmental neuroscience and psychopathology continues to be a high priority. The proposed multi-disciplinary training approach is guided by a conceptual model that recognizes that the risk, onset, and course of psychiatric disorders arises through a complex interplay of brain developmental processes influenced by environmental, psychosocial, cognitive, affective, genetic, and biological factors that interact beginning in utero and continue throughout development. Numerous investigators at Washington University in St. Louis (WUSTL) have a rich track record of experience in many aspects of child neuroimaging and related methods, including a focus on structural and functional magnetic resonance approaches in very early childhood (including neonates), functional near-infrared spectroscopy (fNIRS), evoked response potentials (ERP) and high density diffuse optical tomography (HD- DOT). Further, WUSTL has an international reputation in psychiatric genetics, gut microbiome work, and sleep/circadian rhythms, with many researchers who can bring their expertise to bear on understanding the neurobiology of developmental psychopathology. The program mentors have a rich body of available databases derived from longitudinal studies, several of which began in early childhood and in utero. Mentors also provide a unique multidisciplinary training environment in which to pursue this exciting domain focused on development, given the established collaborations between child researchers in the WUSTL School of Medicine clinical and basic departments, and the state of the program in neuroscience and neuroimaging at WUSTL that has been at the forefront of developmental cognitive and affective neuroscience. Interactions between researchers in basic and clinical developmental neuroscience offer an ongoing opportunity to help train the next generation of young scientists who can pursue questions about the developmental etiology of psychopathology from the perspective of core psychological and neural mechanisms of human behavior that span traditional boundaries of psychopathology, an approach central to the NIMH Research Domain Criteria Initiative (RDOC).