National Alzheimer's Coordinating Center

项目总结 在过去的23年里，国家阿尔茨海默氏症协调中心(NACC)与42个 阿尔茨海默病研究中心(ADRC)在全国范围内建设最大的(46,000+)中心之一 参与者)，世界上最古老、最强大的标准化和纵向阿尔茨海默氏症数据集。自.以来 我们最新的竞争更新，NACC，与NIA和其他ADRC计划密切协调 利益攸关方，已经确定了对全面实施NACC至关重要的领域的重大差距 U24家长奖。必须紧急填补这些差距，以满足ADRC方案不断变化的需求 以及阿尔茨海默氏症和相关痴呆症(ADRD)领域，并履行NACC的使命。NACC将召开会议 这些挑战和放大了NACC和ADRC通过这一行政管理对ADRD研究的影响 通过加快NACC基础设施的现代化和扩大NACC作为 ADRC计划的数据、协作和通信中心。拟议的新研究目标 在这项行政副刊内，涉及重大的意外开支。它们是员工密集型的，而且 需要对新平台进行投资。我们已经制定了一个全面的战略来重组我们的团队 并建立必要的技术和方案基础设施，以满足这些需求。NACC将 构建现代精简的基于云的NACC数据平台和数据前门，以实现集成和共享 来自ADRC计划和其他ADRD数据的现有和创新的标准化多模式数据 协调中心。我们还将改进参与者数据如何通过NACC流动的流程。我们会 与其他ADRD协调中心和倡议密切合作，以改进和创建新的 整合和传播标准MRI/PET图像、基因和生物标记物数据的机会。我们 还将与ADRC成员网站合作，试点多点数字神经病理和数字认知测试 数据收集和集成。此外，我们将通过重新想象的沟通和 采用新途径的协作战略，以传播影响并改善我们对亚洲发展研究中心的便利 财团治理和协作，并为ADRC团体和倡议提供额外支持。最后，我们 正在通过为ADRC创建入口以招募和留住更多参与者来提高ADRC数据的多样性 历史上受到ADRD严重影响的人口微区化。总之，这项工作扩大了NACC的影响和 作为ADRC计划的数据、协作和协调中心的工作范围，目的是显著 提高ADRC的研究影响力。

PROJECT SUMMARY Over the past 23 years, the National Alzheimer’s Coordinating Center (NACC) has collaborated with 42 Alzheimer’s Disease Research Centers (ADRCs) across the country to build one of the largest (46,000+ participants), oldest, and most powerful standardized and longitudinal Alzheimer’s datasets in the world. Since our most recent competitive renewal, NACC, working in close coordination with NIA and other ADRC Program stakeholders, has identified significant gaps in areas that are critical for delivering on the full scope of NACC’s U24 parent award. These gaps must be urgently addressed to meet the evolving needs of the ADRC Program and the Alzheimer’s Disease and Related Dementia (ADRD) field and to fulfill NACC's mission. NACC will meet these challenges and amplify the impact of NACC and the ADRCs on ADRD research through this administrative supplement by accelerating the modernization of NACC infrastructure and by expanding NACC’s role as the data, collaboration, and communication hub for the ADRC Program. The proposed new research objectives within this administrative supplement involve significant unanticipated expenses. They are staff-intensive and require investments in new platforms. We have developed a comprehensive strategy for restructuring our team and for building the required technical and programmatic infrastructure to respond to these needs. NACC will build a modern streamlined cloud-based NACC Data Platform and Data Front Door for integrating and sharing existing and innovative standardized multimodal data from across the ADRC Program and other ADRD data coordinating centers. We will also improve processes for how participant data flows through NACC. We will collaborate closely with other ADRD Coordinating Centers and initiatives to improve and create new opportunities for integration and dissemination of standard MRI/PET images, genetic, and biomarker data. We will also collaborate with ADRC member sites to pilot multisite digital neuropathology and digital cognitive test data collection and integration. Additionally, we will improve our reach through a reimagined communication and collaboration strategy with new pathways to disseminate impact as well as improve our facilitation of ADRC consortium governance and collaboration with additional support for ADRC groups and initiatives. Finally, we are improving ADRC data diversity by creating onramps for ADRCs to recruit and retain more participants from historically minoritized populations highly impacted by ADRD. Together, this work amplifies NACC’s impact and scope of work as the data, collaboration, and coordination hub for the ADRC Program with the aim of significantly improving ADRC research impact.