Photoreceptor Function in ROP

项目摘要/摘要 这是申请一年的补充资金，以执行视网膜阈值测量，这是 父母资助的目标4的中心部分，EY-10597-25，“ROP中的光感受器功能。”COVID完全关闭 在研究过程中，没有参与者进入实验室进行测试。这包括经常脆弱的婴儿和儿童。 有早产史的，他们是目标4的对象。这些婴儿和儿童有严重的 ROP，指定为1型。在早期婴儿时期，他们的视网膜曾接受激光或玻璃体内注射 贝伐单抗(IVB)。我们建议从111名临床特征良好的1型ROP患者中招募新成员， 其中一半使用激光治疗，另一半使用IVB治疗。我们将测量它们对黑暗适应的视觉阈值 在10°和30°偏心时，使用我们先前验证的心理物理程序。我们的总体目标是学习 更多关于1型ROP的视网膜功能的发展，特别是视网膜功能与 屈光发育。早期高度近视是I型ROP的公认并发症，尤其是激光术后 治疗；接受IVB治疗的人近视较少，也不太严重。我们的初步数据，在 这一应用使我们得出了这些可检验的假设：(1)近中心阈值，偏心10°，将是 激光治疗组显著升高，但IVB治疗组未见显著升高；将与健康、 足月出生的对照。(2)偏心阈值越大，偏心程度越大，30°偏心与球形度显著相关 等价物。我们将使用线性混合效应模型来评估这些假设。分析中的因素将 BE组(激光与IVB)、阈值年龄以及患者的临床特征，包括球形 同等的和敏锐的。这一补充工作将很好地补充屈光和屈光的回顾分析 我们能够使用在冠状病毒感染前收集的数据来完成视力发展。

PROJECT SUMMARY/ABSTRACT This is a request for one year's supplemental funding, to perform the retinal threshold measurements that were the centerpiece of Aim 4 of the parent grant, EY-10597-25, “Photoreceptor Function in ROP.” COVID completely shut down the study, and no participants came into the lab for testing. This included the often-fragile infants and children with a history of preterm birth, who are the subject of Aim 4. These infants and children have a history of severe ROP, designated Type 1. In early infancy their retinas had been treated with either laser or intravitreal injection of bevacizumab (IVB). We propose to recruit from a pool of 111 clinically well characterized Type 1 ROP patients, half of them treated using laser, the others treated using IVB. We will measure their dark-adapted visual thresholds at 10° and 30° eccentricities using our previously validated psychophysical procedure. Our overall goal is to learn more about the development of retinal function in Type 1 ROP, particularly the relationship of retinal function to refractive development. Early high myopia is a recognized complication of Type 1 ROP, especially following laser treatment; myopia is less frequent and less severe in those treated using IVB. Our preliminary data, presented in the application, led us to these testable hypotheses: (1) The near central threshold, 10° eccentric, will be significantly elevated in the laser treated but not the IVB treated; comparisons will be made to thresholds in healthy, term-born controls. (2) The more eccentric threshold, 30° eccentric, is significantly associated with spherical equivalent. We will use linear mixed-effects modeling to evaluate these hypotheses. Factors in the analyses will be group (laser vs. IVB), age at threshold test, as well as patients' clinical characteristics, including spherical equivalent and acuity. This supplemental effort will nicely complement the retrospective analyses of refractive and acuity development that we were able to complete using data gathered pre-COVID.