Biological and mechanical therapies enabled by cardiovascular interventional MRI

在过去的一年里，我们继续我们的工作，应用快速核磁共振来指导简单和复杂的机械和生物干预。 我们正在开发临床级别的导管设备，以再通慢性周围动脉完全闭塞。其他导管设备也在开发中，用于动物的实时核磁共振程序和新颖的X射线引导程序。 我们正在开发基于导管的二尖瓣成形术来治疗功能性二尖瓣关闭不全。我们在二尖瓣关闭不全的猪缺血性心肌病模型上取得了额外的成功。 我们继续开发在临床前和临床导管操作过程中，将先前MRI衍生的感兴趣区域与实时X射线相结合或融合的方法。例如，我们的X射线与核磁共振(XFM)融合系统为非手术二尖瓣修复提供了一种新的方法。我们还展示了XFM引导下的膜性室间隔缺损的修复，这是一种通常需要手术修复的先天性心脏病。 我们继续为实时核磁共振治疗人类疾病的临床测试做准备，包括阻塞性外周动脉粥样硬化。

During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We are developing clinical-grade catheter devices to recanalize chronic total occlusions of peripheral arteries. Other catheter devices also are under development for real-time MRI procedures in animals and for novel X-ray guided procedures. We are developing catheter-based mitral annuloplasty to treat functional mitral valve regurgitation. We have additional success in porcine models of ischemic cardiomyopathy mitral valve regurgitation. We continue to develop methods to combine or fuse prior MRI-derived regions of interest with real-time X-ray during preclinical and clinical catheter-based procedures. For example, our X-ray Fused with MRI (XFM) system enables a novel approach to non-surgical mitral valve repair. We also demonstrated XFM guided repair of membranous ventricular septal defect, a congenital heart disease usually requiring surgical repair. We continue to prepare for clinical testing of real-time MRI to treat human disease, including obstructive peripheral artery atherosclerosis.