Clinical and Translational Science Center (UL1)

临床与翻译科学中心(CTSC)的发展完成了推动 全国临床研究企业将翻译研究从长凳无缝转移到床边和 社区。该中心代表着我们的愿景，将最新生物医学进展的广泛知识传递给 有意义的医疗实践的临床应用和培育多学科的转化性研究 教育和培训。CTSC的设计目的是捕捉智力资本的集合，尖端 合作机构的资源和多样化的患者基础，并将它们整合在一起，以实现最大限度的翻译 研究收益。 作为牵头机构，威尔·康奈尔医学中心(WCMC)将作为学术之家，通过 基本资源、技术工具和教育项目可以有效地共享和管理。这个 组成CTSC的伙伴机构也是位于约克大道的邻居。在紧邻区域内 WCMC，包括威尔·康奈尔医学院、威尔·康奈尔医学研究生院和 纽约长老会医院威尔·康奈尔校区；纪念斯隆-凯特琳癌症中心；以及 特外科医院。曼哈顿东区附近有：亨特学院学院 护理，亨特学院基因结构和功能研究中心/少数民族研究中心 机构和康奈尔大学在纽约市的合作扩展。所产生的集群 各机构形成了一个独特的、具有凝聚力的生物医学综合体，满足了NIH拆分路线图的倡议 机构和学科竖井，以加快翻译研究。另外，合作机构是 卓越的智力和学术卓越中心，因此他们融入CTSC将利用他们的 独具特色，加速临床和转化性研究突破，改善患者护理。 本申请中概述的跨机构治理结构，并辅之以全面的 以系统为基础的评价过程对于克服官僚作风和障碍很重要。 制定了新的计划，扩大了合作伙伴之间有合作历史的计划 并进行了重组。CTSC的关键要素是：1)开发新的临床和翻译 方法学；2)试验性和协作性翻译和临床研究；3)生物医学信息学；4)设计， 生物统计学和临床研究伦理；5)监管知识和支持；6)参与者和临床 互动资源；7)社区参与和研究；8)翻译技术和资源；9) 研究教育、培训和职业发展；以及10)其他计划职能。反恐委员会是至关重要的一环。 合作机构的学术、研究和临床实践职能之间的关系，将提供重要的 翻译研究的连续体。

The development of the Clinical and Translational Science Center (CTSC) fulfills the mission to advance the nation's clinical research enterprise of moving translational research seamlessly from bench to bedside and to the community. The Center represents our vision to deliver the vast knowledge of recent biomedical advances to clinical application for meaningful healthcare practices andto nurture multidisciplinary translational research education and training. The CTSC has been designed to capture the collective of intellectual capital, cutting-edge resources and diverse patient base of partnering institutions and to integrate them for maximum translational research benefits. As lead institution, Weill Cornell Medical Center (WCMC) will serve as an academic home through which essential resources, technological tools and education programs can be efficiently shared and managed. The partner institutions comprising the CTSC are also neighbors located on York Avenue. Within the immediate area are: WCMC, including Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences and the Weill Cornell Campus of NewYork-Presbyterian Hospital; Memorial Sloan-Kettering Cancer Center; and the Hospital for Special Surgery. In close proximity on the East Side of Manhattan are: Hunter College School of Nursing, Hunter College Center for the Study of Gene Structure and Function/Research Center for Minority Institutions and the Cornell University Cooperative Extension in New York City. The resulting cluster of institutions forms a unique and cohesive biomedical complex fulfilling the NIH roadmap initiative of breaking-down institutional and disciplinary silos to accelerate translational research. Separately, the partner institutions are superb centers of intellectual and academic excellence, thus their integration into the CTSC will harness their distinctive characteristics and hasten clinical and translational research breakthroughs for improved patient care. The trans-institutional governance structure outlined in this application and supplemented by a comprehensive systems-based evaluation process are important in overcoming bureaucracies and barriers. New initiatives were sculpted and programs with a history of collaboration between partners were broadened and restructured. The key elements of the CTSC are: 1) development of novel clinical and translational methodologies; 2) pilot and collaborative translational and clinical studies; 3) biomedical informatics; 4) design, biostatistics and clinical research ethics; 5) regulatory knowledge and support; 6) participant and clinical interaction resources; 7) community engagement and research; 8) translational technologies and resources; 9) research education, training and career development; and 10) other program functions. The CTSC is a vital link between the academic, research and clinical practice functions of partner institutions and will provide an important continuum in translational research.