Biostatistics and Bioinformatics Core

本研究项目的目的是提高我们对胸腺白血病和淋巴瘤分子途径的理解，以及这些途径如何相互作用。许多拟议的实验涉及操纵小鼠品系的基因表达，并探索其他基因表达改变的后果以及动物胸腺疾病的发病率和时间。预期这五个项目的结果将相互通报。项目结果将在生物统计核心成员的协助下传达给该计划的其他成员。这个

The objective of the research projects in this application is to improve our understanding of the molecular pathways to thymic leukemia and lymphoma, and how these pathways interact. Many of the proposed experiments involve manipulating gene expression in strains of mice, and exploring the consequences both in terms of alteration of expression of other genes and on the incidence and timing of thymic disease in the animals. It is anticipated that the results of these five projects will inform one another. Project results will be conveyed to other members of the program with the assistance of members of the Biostatistics Core. The Biostatistics Core will assist all the research projects contained in this program. The purpose of the Biostatistics Core, Core B, is to provide the following services that will be utilized by the research projects included in this Program Project. 1. To provide biostatistical collaboration for animal studies, including the laboratory components of those studies, for Projects 2, 3, and 4. This will include all aspects of the design and analysis of such studies. 2. To provide biostatistical support for the laboratory studies conducted in cell lines and on murine samples in Projects 1 and 5.