Center for Zoonotic and Emerging Infectious Diseases

动物传染病和新出现的传染病对全球环境构成日益严重的真实的威胁， 我们必须扩大对这些疾病的发病机制和预防的了解， 由于人口密度的增加， 动物种群，以及野生动物拥挤到人类频繁接触的有限区域。到 为了满足对传染病研究能力的需求， 在蒙大拿州立大学（MSU）成立，目标是将蒙大拿州定位为国家 在人畜共患传染病发病机制研究方面处于领先地位。在过去四年中， 该中心非常成功，在基础设施、招聘和支持方面取得了进展 初级调查员，并形成一个有凝聚力的调查员中心。这些因素的协同作用 这些因素为传染病的蔓延奠定了坚实的基础， 该地区的研究。有了这些基础设施，我们现在可以理想地扩展， 加强中心作为一个可扩展和可持续的研究企业。 我们的长期目标是建立一个可持续的卓越中心，专注于了解 人畜共患病和新发传染病的发病机制、宿主免疫反应和治疗进展 具有区域和全球重要性的疾病。虽然这一目标的基础已经建立， 尽管在COBRE I期间取得了一些成就，但仍然迫切需要进一步的师资力量 发展、加强基础设施和招聘更多的人畜共患病领域的研究人员 和新出现的传染病，并提出了三个具体目标，以满足这些需要。一是 建议建立一个管道，以促进现有初级调查员的发展， 在他们职业生涯的关键时刻，资源是可用的。第二，我们建议扩大规模， 范围，和中心的竞争力，通过四个新的教师招聘。共同完成 这两个目标将导致建立维持该中心所需的调查人员的临界质量 并支持未来的传染病研究计划。最后，我们建议加强传染性 通过支持和加强已建立的COBRE核心，在蒙大拿州建立疾病研究基础设施 设施由于COBRE I的成功，中心调查人员的科学能力得到了证实， 杰出的机构支持，以及对一个及时和日益重要的研究领域的重视， 我们相信，COBRE II的支持将导致一个可扩展和可持续的卓越中心的完成 动物传染病和新发传染病的研究。

Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the need for infectious disease research capabilities, a COBRE Center of Excellence was established at Montana State University (MSU), with the goal of positioning Montana as a national leader in research on the pathogenesis of zoonotic infectious diseases. Over the past four years, the Center has been extremely successful, resulting in development of infrastructure, recruitment and support of junior investigators, and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for expansion of infectious disease research in the region. With this infrastructure in place, we are now ideally poised to expand and strengthen the Center as a scalable and sustainable research enterprise. Our long term goal is to establish a sustainable Center of Excellence that is focused on understanding pathogenesis, host immune responses, and therapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. While the foundation for this goal has been established through accomplishments realized during COBRE I, there is still a critical need for further faculty development, infrastructure enhancement, and recruitment of additional researchers in the area of zoonotic and emerging infectious diseases, and three specific aims are proposed to address these needs. First, we propose a pipeline to foster the development of current junior investigators so that funding and infrastructure resources are available at cntical junctures in their careers. Secondly, we propose to increase the size, scope, and competitiveness of the Center through four new faculty hires. Together, accomplishment of these two aims will lead to establishment of the critical mass of investigators needed to sustain the Center and support future infectious disease research initiatives. Finally, we propose to strengthen the infectious disease research infrastructure in Montana through support and enhancement of established COBRE core facilities. Because of the success of COBRE I, the proven scientific abilities of the Center investigators, the outstanding institutional support, and the emphasis on a timely and increasingly important area of research, we believe that COBRE II support will lead to completion of a scalable and sustainable Center of Excellence in zoonotic and emerging infectious disease research.