Boston University Alzheimer's Disease Core Center

描述（由申请人提供）：波士顿大学阿尔茨海默病中心（BU ADC）促进了对正常衰老、轻度认知障碍（MCI）和痴呆的临床病理相关性的广泛研究; AD的遗传和环境风险和保护因素;神经退行性疾病的发病机制和动物模型;以及预防和治疗AD的干预措施。BU ADC为合格的研究人员提供注册参与者、死后脑组织、DNA和转基因小鼠的访问权，并为创新试点项目提供资金。BU ADC由六个内核组成。行政核心监督BU ADC，确保最佳资源利用，协调和整合BU ADC活动。临床核心招募和全面评估，患者/对照登记处每年有600多名参与者。数据管理和统计核心提供基础设施，以优化信息流，并维护数据库，以确定调查人员可用的资源。神经病理学核心建立准确，全面的神经病理学诊断，促进临床病理学研究，并为研究人员提供组织。教育和信息传输核心进行了广泛的教育，推广和招聘活动，以支持该中心。小鼠育种和分子遗传学中心为研究人员提供转基因小鼠和基因分型服务。BU ADC通过收集并向国家阿尔茨海默病协调中心（NACC）传输统一数据集（UDS）来支持国家AD研究。BU ADC是培训医学和研究生，研究员和初级教师在AD研究的平台。与RFA一致，BU ADC已将重点从晚期痴呆症转移到专注于正常衰老和从正常衰老到MCI的过渡以及痴呆症的早期阶段的研究。BU ADC做出了特别努力，以满足不同种族人口的需求和研究。登记册参与者中有20%是非洲裔美国人。BU ADC与NIH资助的主要血管风险因素和AD研究合作，包括心脏研究，MINUS，ADNI，ADCS，REVEAL和檀香山-亚洲老龄化研究，并领导NACC资助的血管神经病理学联盟。在下一个资助周期中，BU ADC将继续提供必要的资源，以提高研究生产力，帮助产生新的想法，并促进与AD相关的合作研究。

DESCRIPTION (provided by applicant): The Boston University Alzheimer's Disease Center (BU ADC) facilitates a wide range of research on clinical-pathological correlations in normal aging, mild cognitive impairment (MCI) and dementia; genetic and environmental risk and protective factors for AD; pathogenesis and animal models of neurodegeneration; and interventions to prevent and treat AD. The BU ADC provides access to registry participants, postmortem brain tissue, DNA and transgenic mice to qualified investigators and funds innovative pilot projects. The BU ADC is composed of six cores. The Administrative Core oversees the BU ADC, ensures optimal resource utilization and coordinates and integrates BU ADC activities. The Clinical Core recruits and comprehensively evaluates, a Patient/Control Registry with more than 600 participants annually. The Data Management and Statistics Core provides infrastructure to optimize the information flow and maintains databases to define resources available to investigators. The Neuropathology Core establishes accurate, comprehensive neuropathological diagnoses, facilitates clinicopathological studies, and provides tissue to investigators. The Education and Information Transfer Core conducts a wide range of education, outreach, and recruitment activities to support the Center. The Murine Breeding and Molecular Genetics Core provides transgenic mice and genotyping services to investigators. The BU ADC supports national AD research by collecting and transmitting a uniform data set (UDS) to the National Alzheimer's Coordinating Center (NACC). The BU ADC is a platform for training medical and graduate students, fellows and junior faculty in AD research. Consistent with the RFA, the BU ADC has shifted focus from late stage dementia to concentrate on research on normal aging and the transition from normal aging to MCI and to the earliest stages of dementia. The BU ADC has made a special effort to address the needs of, and research with, ethnically diverse populations. Twenty percent of Registry participants are African American. The BU ADC collaborates with major NIH-funded studies on vascular risk factors and AD including the Framingham Heart Study, MIRAGE, ADNI, ADCS, REVEAL and the Honolulu-Asian Aging study and leads a NACC-funded Vascular Neuropathology Consortium. In the next funding cycle the BU ADC will continue to provide essential resources to increase research productivity, help generate new ideas, and facilitate collaborative AD-related research.