UCSF Liver Core Center

总体描述（由申请人提供）： 加州大学弗朗西斯科分校（UCSF）肝脏中心是一个由65名基础和临床科学家组成的跨学科联盟，致力于了解肝脏的生物学和病理学以及肝脏疾病的治疗。自1975年成立以来，该中心在内部执行委员会和外部咨询委员会的指导下不断发展，以迎接新的科学挑战。中心成员的研究福尔斯四个相互关联的主题：（1）肝损伤和修复，（2）祖细胞，生长和发育，（3）肝脏生理学和代谢，（4）肝脏病学的临床和转化研究。这些主题的目的是超越个别肝脏疾病或病症。UCSF肝脏中心的一个显着特点是其强大的临床和转化研究基础。这是由一个新资助的临床和转化研究所在加州大学旧金山分校，以及教师参与了一些nlddk赞助的临床研究网络的支持。同样值得注意的是，该中心与UCSF其他一些有组织的研究单位的整合，包括加州再生医学研究所、人类遗传学研究所、加州定量生物医学研究所和UCSF综合癌症中心。从2007年至2012年，UCSF肝脏中心将运营三个生物医学研究核心：（1）动物技术，（2）细胞生物学和（3）病理学和成像。这些核心将提供研究支持和技术培训，以及新合作的场所和新成员的切入点。该中心还将通过一个丰富的计划促进科学交流;课程包括每月一次的研讨会，其中包括当地和访问科学家，与外部咨询委员会的年度全天务虚会，以及与四个研究主题之一相关的旋转主题的季度半天研讨会。该中心的另一个重要组成部分是其试点/可行性方案。这为初级研究人员和肝脏病学研究的新科学家提供了种子资金。最后，补充试点/可行性方案的是一项新的举措，有望产生巨大的价值。“工具和技术”赠款方案，正如它所命名的，将提供资金，中心成员的目的是利用专门的研究服务中心以外。总体而言，中心的供资基础是稳固的，而且还在不断扩大。该机构的支持很强，中心内外的互动机会很多。该中心的目标是充分利用所有可用资源，促进肝病基础生物学和临床诊断和治疗的发现。

DESCRIPTION, OVERALL (provided by applicant): The Liver Center of the University of California, San Francisco (UCSF) is an interdisciplinary consortium of 65 basic and clinical scientists dedicated to understanding the biology and pathobiology of the liver and the treatment of liver diseases. From its inception in 1975, the Center has undergone continual evolution to meet new scientific challenges under the direction of an Internal Executive Committee and External Advisory Board. Research by Center members falls under four interrelated themes: (1) Liver Injury and Repair, (2) Progenitor Cells, Growth and Development, (3) Hepatic Physiology and Metabolism and (4) Clinical and Translational Research in Hepatology. These themes were designed intentionally to transcend individual liver conditions or diseases. A salient feature of the UCSF Liver Center is its strong foundation of clinical and translational research. This is bolstered by a newly-funded Clinical and Translational Research Institute at UCSF, as well as by faculty participation a number of NlDDK-sponsored Clinical Research Networks. Also noteworthy is the Center's integration with a number of other organized research units at UCSF, including the California Institute for Regeneration Medicine, the Institute of Human Genetics, the California Institute for Quantitative Biomedical Research and the UCSF Comprehensive Cancer Center. From 2007-2012 the UCSF Liver Center will operate three Biomedical Research Cores: (1) Animal Technology, (2) Cell Biology and (3) Pathology and Imaging. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes a monthly seminar featuring local and visiting scientists, an annual full-day retreat with the External Advisory Board, and a quarterly half-day symposium with a rotating topic relevant to one of the four research themes. Another vital component of the Center is its Pilot/Feasibility Program. This provides seed money to junior investigators and to scientists new to investigative hepatology. Finally, complementing the Pilot/Feasibility Program is a new initiative that promises to have great value. The "Tool and Technology" Grant Program, as it is named, will provide funds to Center members for the purpose of utilizing specialized research services outside the Center. Overall, the funding base of the Center is robust and growing. Support from the institution is strong, and opportunities for interactions within and outside the Center are numerous. The objective of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology and clinical diagnosis and treatment of liver diseases.