Evaluation of Sensory Integration Treatment in ASD

描述（由申请人提供）：正如申请请求中所指出的，自闭症谱系障碍（ASD）异质性的一个关键方面是，通常提供的临床干预措施数量相对较多，但支持实施的客观证据有限，甚至没有。感觉统合缺陷（SID）是ASD中一个有争议但被广泛使用的诊断分类，基于感觉统合的治疗（SIT）现在被常规地提供给自闭症谱系障碍儿童，但证据基础极其有限。这项R34提案的目的是完成发展分析，为一项相对大型的随机比较试验做准备，该试验旨在研究常用的感觉统合治疗技术对ASD沟通发展的影响。共有40名ASD参与者将被随机分配到感觉统合（SIT）或关键反应训练（PRT）比较条件。此外，将收集和分析干预前后的多感觉处理行为和神经影像学指标，以确定多感觉处理的变化是否与SIT干预有关。要求提供两年的支助。

DESCRIPTION (provided by applicant): As noted in the request for applications, a key aspect of heterogeneity in autism spectrum disorders (ASD) is a relatively high number of clinical interventions that are commonly provided but have limited or even no objective evidence to support implementation. Sensory integration deficit (SID) is a controversial but widely used diagnostic classification in ASD and sensory integration based treatment (SIT) is now routinely provided to children with autism spectrum disorder, but has an extremely limited evidence base. The purpose of this R34 proposal will be to complete developmental analyses in preparation for a relatively large randomized comparison trial examining the effects of commonly implemented sensory integration treatment techniques on communication development in ASD. A total of 40 participants with ASD will be randomly assigned to either a sensory integration (SIT) or pivotal response training (PRT) comparison condition. In addition, pre-and post intervention behavioral and neuro-imaging measures of multi-sensory processing will be gathered and analyzed to determine whether changes in multi-sensory processing are associated with SIT intervention. Two years of support are requested. PUBLIC HEALTH RELEVANCE: Children with autism spectrum disorder (ASD) display severe disruptions in communication and social interaction. There are many unproven treatments thought to improve the skills that are widely implemented. The purpose of this project will be to evaluate whether sensory integration treatment is associated with improvements in communication and social skills in children with ASD.