Barrett's Esophagus Translational Research Network Coordinating Center

描述（由申请人提供）：Barrett食管转化研究网络（BETRNet）旨在通过回答与食管腺癌（EA）进展相关的关键问题，特别是在癌前阶段，降低该疾病的发病率、发病率和死亡率。范德比尔特英格拉姆癌症中心BETRNet协调中心（VICC-BETRNetCC）将通过实现以下具体目标，在促进这些科学进步方面发挥核心作用：1.确保整个BETRNet的顺利运作，特别是在研究中心之间的互动方面。为了实现这一目标，协调中心将为跨网络通信和互动提供领导、后勤和行政支持;建立BETRNet工作组和小组委员会，为BETRNet研究人员的需求提供各个领域的专业知识;促进BETRNet研究中心与NCI之间的沟通。 2.促进整个BETRNet的数据收集、管理、分析和传播。协调中心将提供用于数据收集和存储的基础设施，在银级或金级的CABIG兼容性。该中心还将开发机制，以确保整个BETRNet的机构始终了解网络内可用的数据和资源，因为这些数据和资源将继续通过跨学科研究开发。此外，协调中心将可协助整个研究网络的研究设计和统计分析，特别是关于高维组学研究，包括最新技术（例如，RNAseq）。 3.建立一个多机构患者登记处，以保存临床、纵向和流行病学数据，以及与每个BETRNet站点可用的生物标本相关的数据集。 4.为BETRNet制定和应用评估指标。评估结果将允许中期修正，以帮助最大限度地提高BETRNet倡议的研究生产力和效率。 公共卫生相关性：相关性（参见说明）：虽然EA是一种相对罕见的癌症，但在美国，这种疾病的发病率比任何其他癌症的发病率都要快;而且，在发现时，大多数患者都患有不治之症。EA的惊人增加，沿着不良预后，需要改善患者管理和制定预防措施。这些领域的进展将对降低发病率和死亡率以及降低管理晚期EA的公共卫生成本产生重大益处。

DESCRIPTION (provided by applicant): The Barrett's Esophagus Translational Research Network (BETRNet) has been proposed to reduce the incidence, morbidity, and mortality of esophageal adenocarcinoma (EA), through answering key questions related to the progression of this disease, especially in the premalignant stage. The Vanderbilt-lngram Cancer Center BETRNet Coordinating Center (VICC-BETRNetCC) will have a central role to play in facilitating these scientific advances, by achieving the following specific aims: 1. Ensure smooth functioning of the entire BETRNet, especially with regard to interaction among research centers. To achieve this goal, the coordinating center will provide leadership, logistical, and administrative support for cross-network communication and interaction; establish BETRNet working groups and subcommittees to provide expertise in various areas relevant to the needs of BETRNet investigators; and facilitate communication between BETRNet research centers and the NCI. 2. Facilitate data collection, management, analysis, and dissemination across the BETRNet. The coordinating center wiil provide infrastructure for data collection and storage, at the silver or gold level of caBIG compatibility. The center also will develop mechanisms to ensure that institutions across the BETRNet remain informed of the data and resources available within the network, as these data and resources continue to be developed through trans-disciplinary research. Moreover, the coordinating center will be available to assist with study design and statistical analysis across the research network, especially with regard to high-dimensional omics studies, including the latest technologies (e.g., RNAseq). 3. Develop a multi-institutional patient registry to house clinical, longitudinal, and epidemiological data, as well as datasets relevant to biospecimens available at each BETRNet site. 4. Develop and apply evaluation metrics for the BETRNet. Results of this evaluation will allow for mid-course corrections, to help maximize research productivity and efficiency within the BETRNet initiative. PUBLIC HEALTH RELEVANCE: RELEVANCE (See instructions): Although EA is a relatively uncommon cancer, the incidence of this disease is increasing faster than that of any other cancer in the United States; moreover, at the time of detection, most patients have incurable disease. The alarming increase in EA, along with the poor prognosis, demand improved patient management and development of preventive measures. Advances in these areas will have significant benefit in reducing morbidity and mortality, as well as reducing the public health costs of managing EA at advanced stages.