CNC HIV Anti-viral Therapy Effects Research (CHARTER) Extension

CNS HIV抗逆转录病毒治疗效果研究（CHARTER）是响应RFA NIMH-00-AI-0005于2002年资助的，目的是探索在高活性抗逆转录病毒治疗（HAART）的背景下HIV神经系统并发症的变化。CHARTER的主要目的是确定不同的抗逆转录病毒治疗史和治疗方案如何影响艾滋病毒的中枢和周围神经系统并发症。

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) was funded in 2002 in response to RFA NIMH-00-AI-0005 with the aim of exploring the changing presentation of HIV neurological complications in the context of highly active antiretroviral therapy (HAART). CHARTER¿s major aims were to determine how central and peripheral nervous system complications of HIV were being affected by different histories and regimens of ART. To address these initial aims, CHARTER identified six performance sites (Johns Hopkins University, Mt. Sinai Medical School, University of California at San Diego, University of Texas Medical Branch at Galveston, University of Washington, Washington University at St. Louis), representing a diverse participant pool as well as investigators with expertise in various aspects of neuroAIDS. Standardized neuromedical, neurolopsychological, psychiatric, neuropathy, and imaging protocols were implemented, along with on-going quality assurance procedures. To date, CHARTER has examined 1599 participants cross-sectionally, 674 participants longitudinally over 3210 visits, and is currently following 289 participants through August 2010. Numerous important findings have emanated from both CHARTER investigators and external researchers using CHARTER-generated data and samples. Two key conclusions to emerge from the CHARTER project are that HIV-associated neurocognitive disorders (HAND) and peripheral neuropathy remain highly prevalent despite effective HIV treatments that have significantly reduced mortality and non-neurologic morbidities.