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中文摘要
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太平洋西北尤德尔中心(PANUC)是俄勒冈健康与科学大学和华盛顿大学的医生和科学家的合作企业,专注于认知障碍方面的丰富经验和专业知识,这是一种相对较少了解但毁灭性的后果,在帕金森病患者(PD)中很常见。这个拟议中的新尤德尔中心将是俄勒冈州或世界自然保护区地区唯一的一个;WWAMI是太平洋西北各州合作安排的首字母缩略词,其中华盛顿大学是唯一的医学院和学术医疗中心:华盛顿,怀俄明州,阿拉斯加州,蒙大拿州和爱达荷州。因此,PANUC将覆盖超过整个美国四分之一的面积,其中有1300多万美国人居住。PANUC将实现NIH和NINDS的几个目标。PANUC是:突出以患者为导向,专注于PD的常见非运动特征,这是相对较差的理解,组织成高度相互关联的核心和项目,将促进临床,转化和基础研究之间的新知识交流,渴望为PD数据组织中心(PD- doc)和科里埃尔研究所充分贡献,提交给NINDS人类基因库。他们组成的调查人员虽然在两家机构工作,但长期以来都有着高度的合作效率。我们的使命是双重的。首先,PANUC将为PD患者及其护理人员和医疗保健提供者提供服务。我们将提供更好的教育和临床护理,并为参与临床研究提供新的机会。其次,PANUC将利用来自已完成和合作实验室的一系列尖端技术,发现和研究帕金森病认知障碍的机制,为专注于帕金森病的科学家社区提供新的资源,并确定未来治疗发展的潜在目标。
英文摘要
The Pacific Northwest Udall Center (PANUC) is a collaborative enterprise among physicians and scientists at Oregon Health & Science University and the University of Washington that focuses considerable experience and expertise on cognitive impairment, a relatively poorly understood but devastating consequence that is common in patients afflicted with Parkinson's disease (PD). This proposed new Udall Center would be the only one in Oregon or the WWAMl region; WWAMI is an acronym for the cooperative arrangement among states in Pacific Northwest for which the University of Washington is the only medical school and academic medical center: Washington, Wyoming, Alaska, Montana, and Idaho. Thus, PANUC would cOver an area greater than one-fourth of the entire U.S.A. where more than 13 million Americans live. PANUC will achieve several goals of the NIH and NINDS. PANUC is: eminently patient-oriented, focused on a common non-motor feature of PD that is relatively poorly understood, organized into highly inter-related cores and projects that will promote exchange of new knowledge among clinical, translational, and basic research, anxious to contribute fully to the PD Data Organizing Center (PD-DOC) and the Coriell Institute for submission to the NINDS Human Genefics Repository, and composed of investigators who have a longstanding track record of highly collaborative productivity despite being at two institutions. Our mission is twofold. First, PANUC will serve PD patients, along with their caregivers and health care providers. We will provide improved education and clinical care, as well as offer new opportunities to participate in clinical research. Second, PANUC will discover and investigate the mechanisms that underlie cognitive impairment in PD using an array of cutting-edge technologies from accomplished and collaborative laboratories, generating novel resources for the community of scientists focused on PD, and identifying potential targets for future therapeutic development.
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Neuropath Core
Neuropath Core
Neuropath Core
Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry
  • 批准号:
    10359193
  • 项目类别:
  • 资助金额:
    $46.18万
  • 财政年份:
    2020
  • 负责人:
    Thomas J Montine
  • 依托单位:
海外基金