Barrett's Esophagus Translational Research Network Coordinating Center

Barrett食管转化研究网络（BETRNet）已被提议用于减少 食管腺癌（EA）的发病率、发病率和死亡率，通过回答关键问题 与这种疾病的进展有关，特别是在癌前阶段。范德比尔特-英格拉姆 癌症中心BETRNet协调中心（VICC-BETRNetCC）将在以下方面发挥核心作用： 通过实现以下具体目标促进这些科学进步： 1.确保整个BETRNet的顺利运作，特别是在研究之间的互动方面 中心.为了实现这一目标，协调中心将提供领导、后勤和行政服务。 支持跨网络通信和互动;建立BETRNet工作组， 小组委员会提供与BETRNet调查人员需求相关的各个领域的专业知识;以及 促进BETRNet研究中心和NCI之间的沟通。 2.促进整个BETRNet的数据收集、管理、分析和传播。的 协调中心将为数据收集和存储提供基础设施，达到银级或金级， CABIG兼容性该中心还将制定机制，以确保整个BETRNet的机构 保持被告知网络内可用的数据和资源，因为这些数据和资源 通过跨学科研究不断发展。此外，协调中心将是 可协助整个研究网络的研究设计和统计分析，特别是 关于高维组学研究，包括最新的技术（例如，RNAseq）。 3.建立一个多机构患者登记处，以保存临床、纵向和流行病学数据， 以及每个BETRNet站点上提供的与生物标本相关的数据集。 4.为BETRNet制定和应用评估指标。评估结果将使中期 更正，以帮助最大限度地提高研究生产力和效率的BETRNet倡议。

The Barrett's Esophagus Translational Research Network (BETRNet) has been proposed to reduce the incidence, morbidity, and mortality of esophageal adenocarcinoma (EA), through answering key questions related to the progression of this disease, especially in the premalignant stage. The Vanderbilt-lngram Cancer Center BETRNet Coordinating Center (VICC-BETRNetCC) will have a central role to play in facilitating these scientific advances, by achieving the following specific aims: 1. Ensure smooth functioning of the entire BETRNet, especially with regard to interaction among research centers. To achieve this goal, the coordinating center will provide leadership, logistical, and administrative support for cross-network communication and interaction; establish BETRNet working groups and subcommittees to provide expertise in various areas relevant to the needs of BETRNet investigators; and facilitate communication between BETRNet research centers and the NCI. 2. Facilitate data collection, management, analysis, and dissemination across the BETRNet. The coordinating center wiil provide infrastructure for data collection and storage, at the silver or gold level of caBIG compatibility. The center also will develop mechanisms to ensure that institutions across the BETRNet remain informed of the data and resources available within the network, as these data and resources continue to be developed through trans-disciplinary research. Moreover, the coordinating center will be available to assist with study design and statistical analysis across the research network, especially with regard to high-dimensional omics studies, including the latest technologies (e.g., RNAseq). 3. Develop a multi-institutional patient registry to house clinical, longitudinal, and epidemiological data, as well as datasets relevant to biospecimens available at each BETRNet site. 4. Develop and apply evaluation metrics for the BETRNet. Results of this evaluation will allow for mid-course corrections, to help maximize research productivity and efficiency within the BETRNet initiative.