Profiling global inflammatory signatures for GPCRs in human macrophages
Profiling global inflammatory signatures for GPCRs in human macrophages
批准号:
nhmrc : 1030169
负责人:
Prof David Fairlie
金额:
$45.86万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
巨噬细胞是免疫系统中重要的白细胞。它们会引发对感染或损伤的炎症反应,但长时间的炎症反应会导致慢性疾病。在这个项目中,我们的目标是更好地了解巨噬细胞如何感知外部环境,外部信号如何触发炎症过程,这如何导致自身免疫性和炎症性疾病,癌症和心血管疾病等疾病,以及如何用药物控制它们。
英文摘要
Macrophages are important white blood cells of the immune system. They trigger inflammatory responses to infection or injury, but prolonged inflammatory responses can lead to chronic diseases. In this project we aim to better understand how macrophages sense the outside environment, how external signals trigger inflammatory processes, how this leads to diseases such as autoimmune and inflammatory diseases, cancer and cardiovascular diseases, and how to control them with drugs.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Super-resolution platform to accelerate biological and molecular research
-
批准号:LE240100134
-
项目类别:Linkage Infrastructure, Equipment and Facilities
-
资助金额:$53.09万
-
财政年份:2024
-
负责人:Prof David Fairlie
-
依托单位:
Compressing small peptides for cell absorption
-
批准号:DP180103244
-
项目类别:Discovery Projects
-
资助金额:$40.43万
-
财政年份:2018
-
负责人:Prof David Fairlie
-
依托单位:
Combating infectious diseases by harnessing macrophage functions
-
批准号:nhmrc : GNT1125316
-
项目类别:Project Grants
-
资助金额:$68.82万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Modulating Protein-Protein Interactions In Disease
-
批准号:nhmrc : GNT1117017
-
项目类别:Research Fellowships
-
资助金额:$86.39万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Combating infectious diseases by harnessing macrophage functions
-
批准号:nhmrc : 1125316
-
项目类别:Project Grants
-
资助金额:$46.96万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Modulating Protein-Protein Interactions In Disease
-
批准号:nhmrc : 1117017
-
项目类别:Research Fellowships
-
资助金额:$59.07万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Engineering peptides into superglues selective for target proteins
-
批准号:DP160104442
-
项目类别:Discovery Projects
-
资助金额:$37.48万
-
财政年份:2016
-
负责人:Prof David Fairlie
-
依托单位:
Engineering Cyclic Peptides For Oral Bioavailability
-
批准号:DP150104609
-
项目类别:Discovery Projects
-
资助金额:$34.7万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Development of antimalarial histone deacetylase inhibitors
-
批准号:nhmrc : GNT1093378
-
项目类别:Development Grants
-
资助金额:$55.68万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Development of antimalarial histone deacetylase inhibitors
-
批准号:nhmrc : 1093378
-
项目类别:Development Grants
-
资助金额:$38.25万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Downsizing A Human Protein To Modulate Inflammatory Diseases
-
批准号:nhmrc : 1084018
-
项目类别:Project Grants
-
资助金额:$34.46万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Anti-Parasitic Drug Discovery in Epigenetics
-
批准号:nhmrc : 1074016
-
项目类别:Targeted Calls
-
资助金额:$18.15万
-
财政年份:2014
-
负责人:Prof David Fairlie
-
依托单位:
Downsizing proteins to equipotent small molecules that activate cells
-
批准号:DP130100629
-
项目类别:Discovery Projects
-
资助金额:$34.11万
-
财政年份:2013
-
负责人:Prof David Fairlie
-
依托单位:
Capturing New Drugs That Selectively Modulate PAR2 Signaling Pathways
-
批准号:nhmrc : 1047759
-
项目类别:Project Grants
-
资助金额:$31.28万
-
财政年份:2013
-
负责人:Prof David Fairlie
-
依托单位:
Small Molecule Modulators of Complement in Metabolism and Obesity
-
批准号:nhmrc : 1028423
-
项目类别:Project Grants
-
资助金额:$45.53万
-
财政年份:2012
-
负责人:Prof David Fairlie
-
依托单位:
Flaviviral proteases as viable targets for antiinfective drugs
-
批准号:nhmrc : 1025883
-
项目类别:Project Grants
-
资助金额:$41.39万
-
财政年份:2012
-
负责人:Prof David Fairlie
-
依托单位:
Research Fellowship
-
批准号:nhmrc : 1027369
-
项目类别:Research Fellowships
-
资助金额:$55.8万
-
财政年份:2012
-
负责人:Prof David Fairlie
-
依托单位:
Protein And Peptide Alpha Turns
-
批准号:DP1096290
-
项目类别:Discovery Projects
-
资助金额:$25.08万
-
财政年份:2010
-
负责人:Prof David Fairlie
-
依托单位:
Protease Activated Receptor 2 Antagonist In Inflammatory Disease
-
批准号:nhmrc : 1000745
-
项目类别:NHMRC Development Grants
-
资助金额:$41.43万
-
财政年份:2010
-
负责人:Prof David Fairlie
-
依托单位:
Common hot spots in protein-activated GPCRs enable discovery of new ligands for mapping of G-protein signalling pathways
-
批准号:DP1093245
-
项目类别:Discovery Projects
-
资助金额:$62.7万
-
财政年份:2010
-
负责人:Prof David Fairlie
-
依托单位:
国内基金
海外基金
登录
查看更多内容
Identification and quantification of primary phytoplankton functional types in the global oceans from hyperspectral ocean color remote sensing
-
批准号:--
-
项目类别:--
-
资助金额:160万元
-
批准年份:2022
-
负责人:李忠平
-
依托单位:
中大尺度原子、分子团簇电子和几何结构的理论研究
-
批准号:21073196
-
项目类别:面上项目
-
资助金额:36.0万元
-
批准年份:2010
-
负责人:黄伟
-
依托单位:
核子自旋结构与高能反应过程的自旋不对称
-
批准号:10975092
-
项目类别:面上项目
-
资助金额:40.0万元
-
批准年份:2009
-
负责人:梁作堂
-
依托单位:
非线性抛物双曲耦合方程组及其吸引子
-
批准号:10571024
-
项目类别:面上项目
-
资助金额:23.0万元
-
批准年份:2005
-
负责人:秦玉明
-
依托单位:
磁层亚暴触发过程的全球(global)MHD-Hall数值模拟
-
批准号:40536030
-
项目类别:重点项目
-
资助金额:120.0万元
-
批准年份:2005
-
负责人:马志为
-
依托单位: