The C-type lectin Mincle exemplifies a new mode of sterile inflammation in cardiovascular disease

该项目调查了两种改变生活的心血管事件，这两种事件对当今澳大利亚人最常见的影响；心脏病发作和中风。这些疾病往往使人衰弱，需要很长的恢复期，对许多人来说，这种疾病是致命的。我们已经证明，阻断免疫成分“Mincle”的作用，可以减少与中风相关的炎症，并促进康复。这个项目着眼于Mincle在大脑和心脏肌肉中的作用，以及为什么阻断Mincle可以保护细胞免受氧气的损失。

This project investigates two of the life-changing cardiovascular events that most commonly impact on Australians today; Heart attack and Stroke. These diseases often leave individuals debilitated with a long recovery period, and for many people the event is fatal. We have shown that blocking the action of an immune component, "Mincle", reduces the inflammation associated with stroke, and improves recovery. This project looks at what Mincle does in brain and heart muscle, and why blocking Mincle protects cells from loss of oxygen.