The development of novel, biofilm-resistant biomaterials

几乎所有长期留置导管的病人都会发生细菌感染。大多数情况下，感染是细菌在导管表面定植的结果。生物医学设备表面的细菌定植是一个重大的健康威胁，因为这种细菌生物膜对传统的抗生素方案具有极强的耐药性。该项目旨在开发新型材料，防止细菌在导管和其他生物医学相关设备上定植。我们的技术是基于从一种海洋藻类中鉴定出的化合物，这种化合物可以防止细菌在其表面定植。同样，我们已经证明，当这些化合物涂在测试表面上时，可以防止细菌在一系列材料上定植。

Almost all patients who are catheterised long term develop a bacterial infection. Most often, the infection is the result of colonisation of the catheter surface by bacteria. Bacterial colonisation of the surface of biomedical devices represents a significant health threat as such bacterial biofilms are extremely resistant to traditional antibiotic regimens. This project aims to develop novel materials that prevent bacterial colonisation on catheters and other biomedical related devices. Our technology is based on compounds identified from a marine alga that prevent bacterial colonisation of its surface. Similarly, we have shown that these compounds, when coated onto test surfaces, prevent bacterial colonisation of a range of materials.