The intracellular replicative niche of Legionella species and Coxiella burnetii.
The intracellular replicative niche of Legionella species and Coxiella burnetii.
批准号:
nhmrc : 566568
负责人:
Prof Elizabeth Hartland
金额:
$35.32万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
该项目将研究导致军团病的细菌如何在人体细胞内存活和生长。我们已经确定了新的细菌蛋白,使军团菌能够操纵正常的宿主细胞过程,从而杀死入侵的细菌。类似的蛋白质也存在于密切相关的细菌——引起q热的柯西菌中。通过确定这些蛋白如何起作用,这项工作可能会导致军团病和相关感染的新治疗方法。
英文摘要
This project will study how the bacterium that causes Legionnaire's disease survives and grows inside human cells. We have identified new bacterial proteins that allow Legionella to manipulate the normal host cell processes involved in killing an invading bacterium. Similar proteins are also present in the closely related organism, Coxiella, which causes Q-fever. By determining how these proteins act, this work may result in new treatments for Legionnaire's disease and related infections.
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会议论文
Interferon mediated control of Legionella infection
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批准号:nhmrc : 1145244
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项目类别:Project Grants
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资助金额:$42.52万
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财政年份:2018
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负责人:Prof Elizabeth Hartland
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依托单位:
Interferon mediated control of Legionella infection
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批准号:nhmrc : GNT1145244
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项目类别:Project Grants
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资助金额:$62.88万
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财政年份:2018
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负责人:Prof Elizabeth Hartland
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依托单位:
Nucleomodulin effectors of the environmental pathogen Legionella
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批准号:DP180102725
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项目类别:Discovery Projects
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资助金额:$28.97万
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财政年份:2018
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负责人:Prof Elizabeth Hartland
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依托单位:
Glycosyltransferase effectors from bacterial enteric pathogens
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批准号:nhmrc : GNT1098826
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项目类别:Project Grants
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资助金额:$77.26万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Glycosyltransferase effectors from bacterial enteric pathogens
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批准号:nhmrc : 1098826
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项目类别:Project Grants
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资助金额:$53.15万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Novel bacterial cysteine proteases targeting innate immunity
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批准号:nhmrc : 1100609
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项目类别:Project Grants
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资助金额:$54.86万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Ubiquitination in Legionella infection
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批准号:nhmrc : GNT1098820
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项目类别:Project Grants
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资助金额:$50.15万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Ubiquitination in Legionella infection
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批准号:nhmrc : 1098820
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项目类别:Project Grants
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资助金额:$34.37万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Novel bacterial cysteine proteases targeting innate immunity
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批准号:nhmrc : GNT1100609
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项目类别:Project Grants
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资助金额:$79.76万
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财政年份:2016
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负责人:Prof Elizabeth Hartland
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依托单位:
Death receptor signaling during E. coli and Salmonella infection
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批准号:nhmrc : 1044061
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项目类别:Project Grants
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资助金额:$39.08万
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财政年份:2013
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负责人:Prof Elizabeth Hartland
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依托单位:
Biology and evolution of intracellular parasitism
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批准号:DP130102689
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项目类别:Discovery Projects
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资助金额:$30.31万
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财政年份:2013
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负责人:Prof Elizabeth Hartland
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依托单位:
The biology, structure and function of bacterial virulence effectors
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批准号:FT0990267
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项目类别:ARC Future Fellowships
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资助金额:$56.26万
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财政年份:2010
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负责人:Prof Elizabeth Hartland
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依托单位:
Contribution of nuclear targeting of the NleE-OspZ family of proteins to Escherichia coli and Shigella virulence
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批准号:nhmrc : 566639
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项目类别:NHMRC Project Grants
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资助金额:$36.17万
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财政年份:2009
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负责人:Prof Elizabeth Hartland
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依托单位:
Host cell targets of bacterial virulence effectors
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批准号:DP0773921
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项目类别:Discovery Projects
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资助金额:$18.25万
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财政年份:2008
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负责人:Prof Elizabeth Hartland
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依托单位:
The host specificity of bacterial pathogens
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批准号:DP0451154
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项目类别:Discovery Projects
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资助金额:$15.67万
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财政年份:2004
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负责人:Prof Elizabeth Hartland
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依托单位:
Identification and characterisation of novel virulence genes in attaching and effacing strains of Escherichia coli
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批准号:nhmrc : 216709
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项目类别:NHMRC Project Grants
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资助金额:$18.76万
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财政年份:2002
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负责人:Prof Elizabeth Hartland
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依托单位:
Characterisation of enterohaemorrhagic Escherichia coli lacking classical virulence markers
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批准号:nhmrc : 194235
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项目类别:NHMRC Project Grants
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资助金额:$9.38万
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财政年份:2002
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负责人:Prof Elizabeth Hartland
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依托单位:
Pathogenesis of infections with enteropathogenic and enterohemorrhagic Escherichia coli
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批准号:nhmrc : 7202
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项目类别:Early Career Fellowships
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资助金额:$3.67万
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财政年份:2000
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负责人:Prof Elizabeth Hartland
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依托单位:
国内基金
海外基金
锌指蛋白ZBTB17调控成纤维细胞衰老的机制研究
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批准号:32000509
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2020
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负责人:马兴杰
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依托单位:
内源性逆转录病毒编码的包膜蛋白HEMO在细胞衰老中的作用及机制研究
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批准号:32000512
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项目类别:青年科学基金项目
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资助金额:24.0万元
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批准年份:2020
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负责人:毛剑
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依托单位: